Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior

Abstract Parental upbringing may affect their offspring’s mental state across the entire lifespan. Overprotective parental child-rearing style may increase the disease burden in the offspring. Furthermore, this child-rearing style may also play a pathogenetic role by transmitting trauma- and stresso...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	E. Ullmann, J. Licinio, A. Barthel, K. Petrowski, T. Stalder, S. R. Bornstein, C. Kirschbaum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3853f617f794240855dbc3c6b80e3f9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a3853f617f794240855dbc3c6b80e3f9
record_format	dspace
spelling	oai:doaj.org-article:a3853f617f794240855dbc3c6b80e3f92021-12-02T12:31:59ZPersistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior10.1038/s41598-017-01718-z2045-2322https://doaj.org/article/a3853f617f794240855dbc3c6b80e3f92017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01718-zhttps://doaj.org/toc/2045-2322Abstract Parental upbringing may affect their offspring’s mental state across the entire lifespan. Overprotective parental child-rearing style may increase the disease burden in the offspring. Furthermore, this child-rearing style may also play a pathogenetic role by transmitting trauma- and stressor-related disorders (TSRD) across generations. Studies with animals have demonstrated that the mother’s immediate and expansive protection of the newborn decreases the limbic-hypothalamic-pituitary-adrenal (LHPA) axis activity in the offspring. However, few studies have investigated how stress impact humans raised in an overprotective manner. In a cross-sectional study with 40 healthy students recalling their overprotective upbringing, we show an increase in the dehydroepiandrostendione (DHEA) concentration and a reduction in the cortisol/DHEA-ratio in hair. Additionally, this child rearing style was associated with heightened indications of mental burden, depressiveness, and sense of coherence. Our results provide insight into the roots and consequences of psychological trauma across several generations. Further investigations focusing particularly on multigenerational transmission in extremely burdened families will augment our results.E. UllmannJ. LicinioA. BarthelK. PetrowskiT. StalderS. R. BornsteinC. KirschbaumNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q E. Ullmann J. Licinio A. Barthel K. Petrowski T. Stalder S. R. Bornstein C. Kirschbaum Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior
description	Abstract Parental upbringing may affect their offspring’s mental state across the entire lifespan. Overprotective parental child-rearing style may increase the disease burden in the offspring. Furthermore, this child-rearing style may also play a pathogenetic role by transmitting trauma- and stressor-related disorders (TSRD) across generations. Studies with animals have demonstrated that the mother’s immediate and expansive protection of the newborn decreases the limbic-hypothalamic-pituitary-adrenal (LHPA) axis activity in the offspring. However, few studies have investigated how stress impact humans raised in an overprotective manner. In a cross-sectional study with 40 healthy students recalling their overprotective upbringing, we show an increase in the dehydroepiandrostendione (DHEA) concentration and a reduction in the cortisol/DHEA-ratio in hair. Additionally, this child rearing style was associated with heightened indications of mental burden, depressiveness, and sense of coherence. Our results provide insight into the roots and consequences of psychological trauma across several generations. Further investigations focusing particularly on multigenerational transmission in extremely burdened families will augment our results.
format	article
author	E. Ullmann J. Licinio A. Barthel K. Petrowski T. Stalder S. R. Bornstein C. Kirschbaum
author_facet	E. Ullmann J. Licinio A. Barthel K. Petrowski T. Stalder S. R. Bornstein C. Kirschbaum
author_sort	E. Ullmann
title	Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior
title_short	Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior
title_full	Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior
title_fullStr	Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior
title_full_unstemmed	Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior
title_sort	persistent lhpa activation in german individuals raised in an overprotective parental behavior
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a3853f617f794240855dbc3c6b80e3f9
work_keys_str_mv	AT eullmann persistentlhpaactivationingermanindividualsraisedinanoverprotectiveparentalbehavior AT jlicinio persistentlhpaactivationingermanindividualsraisedinanoverprotectiveparentalbehavior AT abarthel persistentlhpaactivationingermanindividualsraisedinanoverprotectiveparentalbehavior AT kpetrowski persistentlhpaactivationingermanindividualsraisedinanoverprotectiveparentalbehavior AT tstalder persistentlhpaactivationingermanindividualsraisedinanoverprotectiveparentalbehavior AT srbornstein persistentlhpaactivationingermanindividualsraisedinanoverprotectiveparentalbehavior AT ckirschbaum persistentlhpaactivationingermanindividualsraisedinanoverprotectiveparentalbehavior
_version_	1718394232499077120

Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior

Ejemplares similares