Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study

Objective: We aimed to evaluate the effect of vitamin D supplementation in post-stroke fatigue (PSF) patients with vitamin D deficiency on fatigue symptoms and outcomes.Methods: Patients with primary acute ischemic stroke (AIS) were recruited consecutively from July 2016 to June 2018. Post-stroke fa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Long Wang, Xue-min Zhao, Fu-yu Wang, Jun-Cang Wu, Yu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	post-stroke fatigue vitamin D supplementation outcome Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a386ae31f67746d39a4289473c13d365
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a386ae31f67746d39a4289473c13d365
record_format	dspace
spelling	oai:doaj.org-article:a386ae31f67746d39a4289473c13d3652021-11-05T08:16:31ZEffect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study1664-229510.3389/fneur.2021.690969https://doaj.org/article/a386ae31f67746d39a4289473c13d3652021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.690969/fullhttps://doaj.org/toc/1664-2295Objective: We aimed to evaluate the effect of vitamin D supplementation in post-stroke fatigue (PSF) patients with vitamin D deficiency on fatigue symptoms and outcomes.Methods: Patients with primary acute ischemic stroke (AIS) were recruited consecutively from July 2016 to June 2018. Post-stroke fatigue patients were screened out with the Fatigue Severity Scale (FSS) questionnaire, serum concentrations of 25-hydroxyvitamin D [25-(OH)-D] were assessed with enzyme-linked immunosorbent assay (ELISA), and neurological function was evaluated with FSS and modified Rankin Scale (mRS) scoring criteria. Post-stroke fatigue patients with vitamin D deficiency were divided into two groups: a study group in which patients received vitamin D supplementation (cholecalciferol, 600 IU/day) along with usual care, and a control group in which patients received usual care alone. At the end of 1 and 3 months after treatment, all PSE patients accepted re-measurement of serum vitamin D and re-evaluation of fatigue and neurological function.Results: A total of 532 AIS patients were consecutively recruited to participate in this study. Patients without PSF, non-vitamin D deficiency, pre-stroke fatigue, or vitamin D supplementation were excluded from the study. In addition, patients who were lost to follow-up were also excluded. Finally, 139 out of 532 (26.1%) patients with PSF and vitamin D deficiency received vitamin D supplementation treatment. Fatigue Severity Scale score was significantly lower in the study group than in the control group at 1 month (t = −4.731, p < 0.01) and 3 months (t = −7.937, p < 0.01) after treatment. One month after treatment, mRS score in the study group was lower than that in the control group without statistical difference (t = −0.660, p > 0.05), whereas mRS was significantly higher in the study group than in the control group at 3 months after treatment (t = −4.715, p < 0.01).Conclusions: Our results indicated that vitamin D supplementation could improve fatigue symptoms and neurological outcomes in PSF patients with vitamin D deficiency. Subject to replication in other settings, a randomized controlled trial (RCT) might be undertaken to validate the potential beneficial impact of vitamin D supplementation in post-stroke patients found to be vitamin D deficient.Long WangLong WangXue-min ZhaoFu-yu WangJun-Cang WuYu WangFrontiers Media S.A.articlepost-strokefatiguevitamin DsupplementationoutcomeNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	post-stroke fatigue vitamin D supplementation outcome Neurology. Diseases of the nervous system RC346-429
spellingShingle	post-stroke fatigue vitamin D supplementation outcome Neurology. Diseases of the nervous system RC346-429 Long Wang Long Wang Xue-min Zhao Fu-yu Wang Jun-Cang Wu Yu Wang Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study
description	Objective: We aimed to evaluate the effect of vitamin D supplementation in post-stroke fatigue (PSF) patients with vitamin D deficiency on fatigue symptoms and outcomes.Methods: Patients with primary acute ischemic stroke (AIS) were recruited consecutively from July 2016 to June 2018. Post-stroke fatigue patients were screened out with the Fatigue Severity Scale (FSS) questionnaire, serum concentrations of 25-hydroxyvitamin D [25-(OH)-D] were assessed with enzyme-linked immunosorbent assay (ELISA), and neurological function was evaluated with FSS and modified Rankin Scale (mRS) scoring criteria. Post-stroke fatigue patients with vitamin D deficiency were divided into two groups: a study group in which patients received vitamin D supplementation (cholecalciferol, 600 IU/day) along with usual care, and a control group in which patients received usual care alone. At the end of 1 and 3 months after treatment, all PSE patients accepted re-measurement of serum vitamin D and re-evaluation of fatigue and neurological function.Results: A total of 532 AIS patients were consecutively recruited to participate in this study. Patients without PSF, non-vitamin D deficiency, pre-stroke fatigue, or vitamin D supplementation were excluded from the study. In addition, patients who were lost to follow-up were also excluded. Finally, 139 out of 532 (26.1%) patients with PSF and vitamin D deficiency received vitamin D supplementation treatment. Fatigue Severity Scale score was significantly lower in the study group than in the control group at 1 month (t = −4.731, p < 0.01) and 3 months (t = −7.937, p < 0.01) after treatment. One month after treatment, mRS score in the study group was lower than that in the control group without statistical difference (t = −0.660, p > 0.05), whereas mRS was significantly higher in the study group than in the control group at 3 months after treatment (t = −4.715, p < 0.01).Conclusions: Our results indicated that vitamin D supplementation could improve fatigue symptoms and neurological outcomes in PSF patients with vitamin D deficiency. Subject to replication in other settings, a randomized controlled trial (RCT) might be undertaken to validate the potential beneficial impact of vitamin D supplementation in post-stroke patients found to be vitamin D deficient.
format	article
author	Long Wang Long Wang Xue-min Zhao Fu-yu Wang Jun-Cang Wu Yu Wang
author_facet	Long Wang Long Wang Xue-min Zhao Fu-yu Wang Jun-Cang Wu Yu Wang
author_sort	Long Wang
title	Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study
title_short	Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study
title_full	Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study
title_fullStr	Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study
title_full_unstemmed	Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study
title_sort	effect of vitamin d supplementation on the prognosis of post-stroke fatigue: a retrospective cohort study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a386ae31f67746d39a4289473c13d365
work_keys_str_mv	AT longwang effectofvitamindsupplementationontheprognosisofpoststrokefatiguearetrospectivecohortstudy AT longwang effectofvitamindsupplementationontheprognosisofpoststrokefatiguearetrospectivecohortstudy AT xueminzhao effectofvitamindsupplementationontheprognosisofpoststrokefatiguearetrospectivecohortstudy AT fuyuwang effectofvitamindsupplementationontheprognosisofpoststrokefatiguearetrospectivecohortstudy AT juncangwu effectofvitamindsupplementationontheprognosisofpoststrokefatiguearetrospectivecohortstudy AT yuwang effectofvitamindsupplementationontheprognosisofpoststrokefatiguearetrospectivecohortstudy
_version_	1718444488542650368

Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study

Ejemplares similares