Nuclear receptors: a bridge linking the gut microbiome and the host

Abstract Background The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties of metabolic factors such as short-c...

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Autores principales:	Zixuan Wang, Wei-Dong Chen, Yan-Dong Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Gut microbiome Nuclear receptors Inflammatory bowel disease Obesity Diabetes Therapeutics. Pharmacology RM1-950 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/a386bfb796a345dea47ff6fee4ae0bd4
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spelling	oai:doaj.org-article:a386bfb796a345dea47ff6fee4ae0bd42021-11-07T12:19:17ZNuclear receptors: a bridge linking the gut microbiome and the host10.1186/s10020-021-00407-y1076-15511528-3658https://doaj.org/article/a386bfb796a345dea47ff6fee4ae0bd42021-11-01T00:00:00Zhttps://doi.org/10.1186/s10020-021-00407-yhttps://doaj.org/toc/1076-1551https://doaj.org/toc/1528-3658Abstract Background The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties of metabolic factors such as short-chain fatty acids, bile acids and amino acids. Nuclear receptors, as metabolic mediators, act as a series of intermediates between the microbiome and the host and help the microbiome regulate diverse processes in the host. Recently, nuclear receptors such as farnesoid X receptor, peroxisome proliferator-activated receptors, aryl hydrocarbon receptor and vitamin D receptor have been identified as key regulators of the microbiome-host crosstalk. These nuclear receptors regulate metabolic processes, immune activity, autophagy, non-alcoholic and alcoholic fatty liver disease, inflammatory bowel disease, cancer, obesity, and type-2 diabetes. Conclusion In this review, we have summarized the functions of the nuclear receptors in the gut microbiome-host axis in different physiological and pathological conditions, indicating that the nuclear receptors may be the good targets for treatment of different diseases through the crosstalk with the gut microbiome.Zixuan WangWei-Dong ChenYan-Dong WangBMCarticleGut microbiomeNuclear receptorsInflammatory bowel diseaseObesityDiabetesTherapeutics. PharmacologyRM1-950BiochemistryQD415-436ENMolecular Medicine, Vol 27, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gut microbiome Nuclear receptors Inflammatory bowel disease Obesity Diabetes Therapeutics. Pharmacology RM1-950 Biochemistry QD415-436
spellingShingle	Gut microbiome Nuclear receptors Inflammatory bowel disease Obesity Diabetes Therapeutics. Pharmacology RM1-950 Biochemistry QD415-436 Zixuan Wang Wei-Dong Chen Yan-Dong Wang Nuclear receptors: a bridge linking the gut microbiome and the host
description	Abstract Background The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties of metabolic factors such as short-chain fatty acids, bile acids and amino acids. Nuclear receptors, as metabolic mediators, act as a series of intermediates between the microbiome and the host and help the microbiome regulate diverse processes in the host. Recently, nuclear receptors such as farnesoid X receptor, peroxisome proliferator-activated receptors, aryl hydrocarbon receptor and vitamin D receptor have been identified as key regulators of the microbiome-host crosstalk. These nuclear receptors regulate metabolic processes, immune activity, autophagy, non-alcoholic and alcoholic fatty liver disease, inflammatory bowel disease, cancer, obesity, and type-2 diabetes. Conclusion In this review, we have summarized the functions of the nuclear receptors in the gut microbiome-host axis in different physiological and pathological conditions, indicating that the nuclear receptors may be the good targets for treatment of different diseases through the crosstalk with the gut microbiome.
format	article
author	Zixuan Wang Wei-Dong Chen Yan-Dong Wang
author_facet	Zixuan Wang Wei-Dong Chen Yan-Dong Wang
author_sort	Zixuan Wang
title	Nuclear receptors: a bridge linking the gut microbiome and the host
title_short	Nuclear receptors: a bridge linking the gut microbiome and the host
title_full	Nuclear receptors: a bridge linking the gut microbiome and the host
title_fullStr	Nuclear receptors: a bridge linking the gut microbiome and the host
title_full_unstemmed	Nuclear receptors: a bridge linking the gut microbiome and the host
title_sort	nuclear receptors: a bridge linking the gut microbiome and the host
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a386bfb796a345dea47ff6fee4ae0bd4
work_keys_str_mv	AT zixuanwang nuclearreceptorsabridgelinkingthegutmicrobiomeandthehost AT weidongchen nuclearreceptorsabridgelinkingthegutmicrobiomeandthehost AT yandongwang nuclearreceptorsabridgelinkingthegutmicrobiomeandthehost
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Nuclear receptors: a bridge linking the gut microbiome and the host

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