Accurate estimation of cell-type composition from gene expression data

Bulk RNA-seq data harbors valuable information about gene expression levels from different cell types in tissue samples. Here, the authors develop DWLS, a computational method for estimating cell-type composition of bulk data by leveraging single-cell RNA-seq-derived cell-type signatures.

Guardado en:

Detalles Bibliográficos
Autores principales:	Daphne Tsoucas, Rui Dong, Haide Chen, Qian Zhu, Guoji Guo, Guo-Cheng Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a386c685ecc44f67a8f77ffcb1d966eb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a386c685ecc44f67a8f77ffcb1d966eb
record_format	dspace
spelling	oai:doaj.org-article:a386c685ecc44f67a8f77ffcb1d966eb2021-12-02T14:35:51ZAccurate estimation of cell-type composition from gene expression data10.1038/s41467-019-10802-z2041-1723https://doaj.org/article/a386c685ecc44f67a8f77ffcb1d966eb2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10802-zhttps://doaj.org/toc/2041-1723Bulk RNA-seq data harbors valuable information about gene expression levels from different cell types in tissue samples. Here, the authors develop DWLS, a computational method for estimating cell-type composition of bulk data by leveraging single-cell RNA-seq-derived cell-type signatures.Daphne TsoucasRui DongHaide ChenQian ZhuGuoji GuoGuo-Cheng YuanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daphne Tsoucas Rui Dong Haide Chen Qian Zhu Guoji Guo Guo-Cheng Yuan Accurate estimation of cell-type composition from gene expression data
description	Bulk RNA-seq data harbors valuable information about gene expression levels from different cell types in tissue samples. Here, the authors develop DWLS, a computational method for estimating cell-type composition of bulk data by leveraging single-cell RNA-seq-derived cell-type signatures.
format	article
author	Daphne Tsoucas Rui Dong Haide Chen Qian Zhu Guoji Guo Guo-Cheng Yuan
author_facet	Daphne Tsoucas Rui Dong Haide Chen Qian Zhu Guoji Guo Guo-Cheng Yuan
author_sort	Daphne Tsoucas
title	Accurate estimation of cell-type composition from gene expression data
title_short	Accurate estimation of cell-type composition from gene expression data
title_full	Accurate estimation of cell-type composition from gene expression data
title_fullStr	Accurate estimation of cell-type composition from gene expression data
title_full_unstemmed	Accurate estimation of cell-type composition from gene expression data
title_sort	accurate estimation of cell-type composition from gene expression data
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a386c685ecc44f67a8f77ffcb1d966eb
work_keys_str_mv	AT daphnetsoucas accurateestimationofcelltypecompositionfromgeneexpressiondata AT ruidong accurateestimationofcelltypecompositionfromgeneexpressiondata AT haidechen accurateestimationofcelltypecompositionfromgeneexpressiondata AT qianzhu accurateestimationofcelltypecompositionfromgeneexpressiondata AT guojiguo accurateestimationofcelltypecompositionfromgeneexpressiondata AT guochengyuan accurateestimationofcelltypecompositionfromgeneexpressiondata
_version_	1718391023902654464

Accurate estimation of cell-type composition from gene expression data

Ejemplares similares