Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics

The diagnosis of food intolerance is tricky due to the different etiologies of adverse reactions. There is also a lack of clear rules for interpreting alternative tests used to diagnose these problems. The analyses of IgG4 concentration in serum or cytotoxic tests became the basis of elimination die...

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Autores principales:	Dorota Myszkowska, Barbara Zapała, Małgorzata Bulanda, Ewa Czarnobilska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	adverse reactions to food alternative tests FLG genes Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a38be243e1334729a3db5b091511b052
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spelling	oai:doaj.org-article:a38be243e1334729a3db5b091511b0522021-11-25T18:18:54ZNon-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics10.3390/medicina571112451648-91441010-660Xhttps://doaj.org/article/a38be243e1334729a3db5b091511b0522021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1245https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144The diagnosis of food intolerance is tricky due to the different etiologies of adverse reactions. There is also a lack of clear rules for interpreting alternative tests used to diagnose these problems. The analyses of IgG4 concentration in serum or cytotoxic tests became the basis of elimination diets. However, it can result in nutritional deficiencies and loss of tolerance to eliminated foods. Our study aimed to assess the necessity of food elimination in four cases with food intolerance symptoms based on alternative diagnostic tests. Four patients without food allergies, who manifested diverse clinical symptoms after food, were presented due to the following factors: clinical history, diagnostic tests, elimination diet, and filaggrin gene (FLG) mutation. It was found that higher IgG4 levels against foods and higher cytotoxic test values are not clinically relevant in each of the studied individuals. They should not be decisive for the elimination of food products. The study of FLG-SNVs revealed the association of some clinical symptoms in patients with hypersensitivity to several food allergens and reported genetic variants in the FLG gene.Dorota MyszkowskaBarbara ZapałaMałgorzata BulandaEwa CzarnobilskaMDPI AGarticleadverse reactions to foodalternative testsFLG genesMedicine (General)R5-920ENMedicina, Vol 57, Iss 1245, p 1245 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adverse reactions to food alternative tests FLG genes Medicine (General) R5-920
spellingShingle	adverse reactions to food alternative tests FLG genes Medicine (General) R5-920 Dorota Myszkowska Barbara Zapała Małgorzata Bulanda Ewa Czarnobilska Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics
description	The diagnosis of food intolerance is tricky due to the different etiologies of adverse reactions. There is also a lack of clear rules for interpreting alternative tests used to diagnose these problems. The analyses of IgG4 concentration in serum or cytotoxic tests became the basis of elimination diets. However, it can result in nutritional deficiencies and loss of tolerance to eliminated foods. Our study aimed to assess the necessity of food elimination in four cases with food intolerance symptoms based on alternative diagnostic tests. Four patients without food allergies, who manifested diverse clinical symptoms after food, were presented due to the following factors: clinical history, diagnostic tests, elimination diet, and filaggrin gene (FLG) mutation. It was found that higher IgG4 levels against foods and higher cytotoxic test values are not clinically relevant in each of the studied individuals. They should not be decisive for the elimination of food products. The study of FLG-SNVs revealed the association of some clinical symptoms in patients with hypersensitivity to several food allergens and reported genetic variants in the FLG gene.
format	article
author	Dorota Myszkowska Barbara Zapała Małgorzata Bulanda Ewa Czarnobilska
author_facet	Dorota Myszkowska Barbara Zapała Małgorzata Bulanda Ewa Czarnobilska
author_sort	Dorota Myszkowska
title	Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics
title_short	Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics
title_full	Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics
title_fullStr	Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics
title_full_unstemmed	Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics
title_sort	non-ige mediated hypersensitivity to food products or food intolerance—problems of appropriate diagnostics
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a38be243e1334729a3db5b091511b052
work_keys_str_mv	AT dorotamyszkowska nonigemediatedhypersensitivitytofoodproductsorfoodintoleranceproblemsofappropriatediagnostics AT barbarazapała nonigemediatedhypersensitivitytofoodproductsorfoodintoleranceproblemsofappropriatediagnostics AT małgorzatabulanda nonigemediatedhypersensitivitytofoodproductsorfoodintoleranceproblemsofappropriatediagnostics AT ewaczarnobilska nonigemediatedhypersensitivitytofoodproductsorfoodintoleranceproblemsofappropriatediagnostics
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Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics

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