Pupil adaptation corresponds to quantitative measures of autism traits in children

Abstract The pupil is known to reflect a range of psychological and physiological variables, including cognitive effort, arousal, attention, and even learning. Within autism spectrum disorder (ASD), some work has used pupil physiology to successfully classify patients with or without autism. As we h...

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Autores principales:	Antoinette Sabatino DiCriscio, Vanessa Troiani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a38c699fe76249749e654034c7274e22
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spelling	oai:doaj.org-article:a38c699fe76249749e654034c7274e222021-12-02T11:40:52ZPupil adaptation corresponds to quantitative measures of autism traits in children10.1038/s41598-017-06829-12045-2322https://doaj.org/article/a38c699fe76249749e654034c7274e222017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06829-1https://doaj.org/toc/2045-2322Abstract The pupil is known to reflect a range of psychological and physiological variables, including cognitive effort, arousal, attention, and even learning. Within autism spectrum disorder (ASD), some work has used pupil physiology to successfully classify patients with or without autism. As we have come to understand the heterogeneity of ASD and other neurodevelopmental disorders, the relationship between quantitative traits and physiological markers has become increasingly more important, as this may lead us closer to the underlying biological basis for atypical responses and behaviors. We implemented a novel paradigm designed to capture patterns of pupil adaptation during sustained periods of dark and light conditions in a pediatric sample that varied in intellectual ability and clinical features. We also investigate the relationship between pupil metrics derived from this novel task and quantitative behavioral traits associated with the autism phenotype. We show that pupil metrics of constriction and dilation are distinct from baseline metrics. Pupil dilation metrics correlate with individual differences measured by the Social Responsiveness Scale (SRS), a quantitative measure of autism traits. These results suggest that using a novel, yet simple, paradigm can result in meaningful pupil metrics that correlate with individual differences in autism traits, as measured by the SRS.Antoinette Sabatino DiCriscioVanessa TroianiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antoinette Sabatino DiCriscio Vanessa Troiani Pupil adaptation corresponds to quantitative measures of autism traits in children
description	Abstract The pupil is known to reflect a range of psychological and physiological variables, including cognitive effort, arousal, attention, and even learning. Within autism spectrum disorder (ASD), some work has used pupil physiology to successfully classify patients with or without autism. As we have come to understand the heterogeneity of ASD and other neurodevelopmental disorders, the relationship between quantitative traits and physiological markers has become increasingly more important, as this may lead us closer to the underlying biological basis for atypical responses and behaviors. We implemented a novel paradigm designed to capture patterns of pupil adaptation during sustained periods of dark and light conditions in a pediatric sample that varied in intellectual ability and clinical features. We also investigate the relationship between pupil metrics derived from this novel task and quantitative behavioral traits associated with the autism phenotype. We show that pupil metrics of constriction and dilation are distinct from baseline metrics. Pupil dilation metrics correlate with individual differences measured by the Social Responsiveness Scale (SRS), a quantitative measure of autism traits. These results suggest that using a novel, yet simple, paradigm can result in meaningful pupil metrics that correlate with individual differences in autism traits, as measured by the SRS.
format	article
author	Antoinette Sabatino DiCriscio Vanessa Troiani
author_facet	Antoinette Sabatino DiCriscio Vanessa Troiani
author_sort	Antoinette Sabatino DiCriscio
title	Pupil adaptation corresponds to quantitative measures of autism traits in children
title_short	Pupil adaptation corresponds to quantitative measures of autism traits in children
title_full	Pupil adaptation corresponds to quantitative measures of autism traits in children
title_fullStr	Pupil adaptation corresponds to quantitative measures of autism traits in children
title_full_unstemmed	Pupil adaptation corresponds to quantitative measures of autism traits in children
title_sort	pupil adaptation corresponds to quantitative measures of autism traits in children
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a38c699fe76249749e654034c7274e22
work_keys_str_mv	AT antoinettesabatinodicriscio pupiladaptationcorrespondstoquantitativemeasuresofautismtraitsinchildren AT vanessatroiani pupiladaptationcorrespondstoquantitativemeasuresofautismtraitsinchildren
_version_	1718395536529162240

Pupil adaptation corresponds to quantitative measures of autism traits in children

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