Impact of nanoparticles on neuron biology: current research trends

Firdos Alam Khan, Dana Almohazey, Munthar Alomari, Sarah Ameen Almofty Department of Stem Cell Biology, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia Abstract: Nanoparticles have enormous applications in textiles, cosmetic...

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Autores principales:	Khan FA, Almohazey D, Alomari M, Almofty SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	nanoparticles neuron biology neuroprotection neurotoxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a38d61399f2c46a2bfe65e450c82ccb5
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spelling	oai:doaj.org-article:a38d61399f2c46a2bfe65e450c82ccb52021-12-02T06:03:45ZImpact of nanoparticles on neuron biology: current research trends1178-2013https://doaj.org/article/a38d61399f2c46a2bfe65e450c82ccb52018-05-01T00:00:00Zhttps://www.dovepress.com/impact-of-nanoparticles-on-neuron-biology-current-research-trends-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Firdos Alam Khan, Dana Almohazey, Munthar Alomari, Sarah Ameen Almofty Department of Stem Cell Biology, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia Abstract: Nanoparticles have enormous applications in textiles, cosmetics, electronics, and pharmaceuticals. But due to their exceptional physical and chemical properties, particularly antimicrobial, anticancer, antibacterial, anti-inflammatory properties, nanoparticles have many potential applications in diagnosis as well as in the treatment of various diseases. Over the past few years, nanoparticles have been extensively used to investigate their response on the neuronal cells. These nanoparticles cause stem cells to differentiate into neuronal cells and promote neuronal cell survivability and neuronal cell growth and expansion. The nanoparticles have been tested both in in vitro and in vivo models. The nanoparticles with various shapes, sizes, and chemical compositions mostly produced stimulatory effects on neuronal cells, but there are few that can cause inhibitory effects on the neuronal cells. In this review, we discuss stimulatory and inhibitory effects of various nanoparticles on the neuronal cells. The aim of this review was to summarize different effects of nanoparticles on the neuronal cells and try to understand the differential response of various nanoparticles. This review provides a bird’s eye view approach on the effects of various nanoparticles on neuronal differentiation, neuronal survivability, neuronal growth, neuronal cell adhesion, and functional and behavioral recovery. Finally, this review helps the researchers to understand the different roles of nanoparticles (stimulatory and inhibitory) in neuronal cells to develop effective therapeutic and diagnostic strategies for neurodegenerative diseases. Keywords: nanoparticles, neuron biology, neuroprotection, neurotoxicityKhan FAAlmohazey DAlomari MAlmofty SADove Medical Pressarticlenanoparticlesneuron biologyneuroprotectionneurotoxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2767-2776 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles neuron biology neuroprotection neurotoxicity Medicine (General) R5-920
spellingShingle	nanoparticles neuron biology neuroprotection neurotoxicity Medicine (General) R5-920 Khan FA Almohazey D Alomari M Almofty SA Impact of nanoparticles on neuron biology: current research trends
description	Firdos Alam Khan, Dana Almohazey, Munthar Alomari, Sarah Ameen Almofty Department of Stem Cell Biology, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia Abstract: Nanoparticles have enormous applications in textiles, cosmetics, electronics, and pharmaceuticals. But due to their exceptional physical and chemical properties, particularly antimicrobial, anticancer, antibacterial, anti-inflammatory properties, nanoparticles have many potential applications in diagnosis as well as in the treatment of various diseases. Over the past few years, nanoparticles have been extensively used to investigate their response on the neuronal cells. These nanoparticles cause stem cells to differentiate into neuronal cells and promote neuronal cell survivability and neuronal cell growth and expansion. The nanoparticles have been tested both in in vitro and in vivo models. The nanoparticles with various shapes, sizes, and chemical compositions mostly produced stimulatory effects on neuronal cells, but there are few that can cause inhibitory effects on the neuronal cells. In this review, we discuss stimulatory and inhibitory effects of various nanoparticles on the neuronal cells. The aim of this review was to summarize different effects of nanoparticles on the neuronal cells and try to understand the differential response of various nanoparticles. This review provides a bird’s eye view approach on the effects of various nanoparticles on neuronal differentiation, neuronal survivability, neuronal growth, neuronal cell adhesion, and functional and behavioral recovery. Finally, this review helps the researchers to understand the different roles of nanoparticles (stimulatory and inhibitory) in neuronal cells to develop effective therapeutic and diagnostic strategies for neurodegenerative diseases. Keywords: nanoparticles, neuron biology, neuroprotection, neurotoxicity
format	article
author	Khan FA Almohazey D Alomari M Almofty SA
author_facet	Khan FA Almohazey D Alomari M Almofty SA
author_sort	Khan FA
title	Impact of nanoparticles on neuron biology: current research trends
title_short	Impact of nanoparticles on neuron biology: current research trends
title_full	Impact of nanoparticles on neuron biology: current research trends
title_fullStr	Impact of nanoparticles on neuron biology: current research trends
title_full_unstemmed	Impact of nanoparticles on neuron biology: current research trends
title_sort	impact of nanoparticles on neuron biology: current research trends
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/a38d61399f2c46a2bfe65e450c82ccb5
work_keys_str_mv	AT khanfa impactofnanoparticlesonneuronbiologycurrentresearchtrends AT almohazeyd impactofnanoparticlesonneuronbiologycurrentresearchtrends AT alomarim impactofnanoparticlesonneuronbiologycurrentresearchtrends AT almoftysa impactofnanoparticlesonneuronbiologycurrentresearchtrends
_version_	1718400126490247168

Impact of nanoparticles on neuron biology: current research trends

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