Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke

Omecamtiv mecarbil (OM) is a positive cardiac inotrope in clinical trials for the treatment of heart failure whose mechanism of action is incompletely understood. Here the authors show that OM inhibits myosin's working stroke and prolongs actomyosin attachment and propose a model that reconcile...

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Autores principales:	Michael S. Woody, Michael J. Greenberg, Bipasha Barua, Donald A. Winkelmann, Yale E. Goldman, E. Michael Ostap
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a390d9a0840145559f69f13c5f0635e6
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spelling	oai:doaj.org-article:a390d9a0840145559f69f13c5f0635e62021-12-02T15:33:46ZPositive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke10.1038/s41467-018-06193-22041-1723https://doaj.org/article/a390d9a0840145559f69f13c5f0635e62018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06193-2https://doaj.org/toc/2041-1723Omecamtiv mecarbil (OM) is a positive cardiac inotrope in clinical trials for the treatment of heart failure whose mechanism of action is incompletely understood. Here the authors show that OM inhibits myosin's working stroke and prolongs actomyosin attachment and propose a model that reconciles the OM-induced increase in cardiac performance in vivo with the inhibitory actions observed in vitro.Michael S. WoodyMichael J. GreenbergBipasha BaruaDonald A. WinkelmannYale E. GoldmanE. Michael OstapNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael S. Woody Michael J. Greenberg Bipasha Barua Donald A. Winkelmann Yale E. Goldman E. Michael Ostap Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
description	Omecamtiv mecarbil (OM) is a positive cardiac inotrope in clinical trials for the treatment of heart failure whose mechanism of action is incompletely understood. Here the authors show that OM inhibits myosin's working stroke and prolongs actomyosin attachment and propose a model that reconciles the OM-induced increase in cardiac performance in vivo with the inhibitory actions observed in vitro.
format	article
author	Michael S. Woody Michael J. Greenberg Bipasha Barua Donald A. Winkelmann Yale E. Goldman E. Michael Ostap
author_facet	Michael S. Woody Michael J. Greenberg Bipasha Barua Donald A. Winkelmann Yale E. Goldman E. Michael Ostap
author_sort	Michael S. Woody
title	Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
title_short	Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
title_full	Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
title_fullStr	Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
title_full_unstemmed	Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
title_sort	positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a390d9a0840145559f69f13c5f0635e6
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Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke

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