Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions.

Parvovirus B19 (B19V) can cause infection in humans. To date, three genotypes of B19V, with subtypes, are known, of which genotype 1a is the most prevalent genotype in the Western world. We sequenced the genome of B19V strains of 65 asymptomatic, recently infected Dutch blood donors, to investigate...

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Autores principales: Marijke W A Molenaar-de Backer, Vladimir V Lukashov, Rob S van Binnendijk, Hein J Boot, Hans L Zaaijer
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Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/a3939d6b3049467ea33a3ffff5b20280
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spelling oai:doaj.org-article:a3939d6b3049467ea33a3ffff5b202802021-11-18T07:08:54ZGlobal co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions.1932-620310.1371/journal.pone.0043206https://doaj.org/article/a3939d6b3049467ea33a3ffff5b202802012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912828/?tool=EBIhttps://doaj.org/toc/1932-6203Parvovirus B19 (B19V) can cause infection in humans. To date, three genotypes of B19V, with subtypes, are known, of which genotype 1a is the most prevalent genotype in the Western world. We sequenced the genome of B19V strains of 65 asymptomatic, recently infected Dutch blood donors, to investigate the spatio-temporal distribution of B19V strains, in the years 2003-2009. The sequences were compared to B19V sequences from Dutch patients with fifth disease, and to global B19V sequences as available from GenBank. All Dutch B19V strains belonged to genotype 1a. Phylogenetic analysis of the strains from Dutch blood donors showed that two groups of genotype 1a co-exist. A clear-cut division into the two groups was also found among the B19V strains from Dutch patients, and among the B19V sequences in GenBank. The two groups of genotype 1a co-exist around the world and do not appear to differ in their ability to cause disease. Strikingly, the two groups of B19V predominantly differ in synonymous mutations, distributed throughout the entire genome of B19V. We propose to call the two groups of B19V genotype 1a respectively subtype 1a1 and 1a2.Marijke W A Molenaar-de BackerVladimir V LukashovRob S van BinnendijkHein J BootHans L ZaaijerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43206 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Marijke W A Molenaar-de Backer
Vladimir V Lukashov
Rob S van Binnendijk
Hein J Boot
Hans L Zaaijer
Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions.
description Parvovirus B19 (B19V) can cause infection in humans. To date, three genotypes of B19V, with subtypes, are known, of which genotype 1a is the most prevalent genotype in the Western world. We sequenced the genome of B19V strains of 65 asymptomatic, recently infected Dutch blood donors, to investigate the spatio-temporal distribution of B19V strains, in the years 2003-2009. The sequences were compared to B19V sequences from Dutch patients with fifth disease, and to global B19V sequences as available from GenBank. All Dutch B19V strains belonged to genotype 1a. Phylogenetic analysis of the strains from Dutch blood donors showed that two groups of genotype 1a co-exist. A clear-cut division into the two groups was also found among the B19V strains from Dutch patients, and among the B19V sequences in GenBank. The two groups of genotype 1a co-exist around the world and do not appear to differ in their ability to cause disease. Strikingly, the two groups of B19V predominantly differ in synonymous mutations, distributed throughout the entire genome of B19V. We propose to call the two groups of B19V genotype 1a respectively subtype 1a1 and 1a2.
format article
author Marijke W A Molenaar-de Backer
Vladimir V Lukashov
Rob S van Binnendijk
Hein J Boot
Hans L Zaaijer
author_facet Marijke W A Molenaar-de Backer
Vladimir V Lukashov
Rob S van Binnendijk
Hein J Boot
Hans L Zaaijer
author_sort Marijke W A Molenaar-de Backer
title Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions.
title_short Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions.
title_full Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions.
title_fullStr Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions.
title_full_unstemmed Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions.
title_sort global co-existence of two evolutionary lineages of parvovirus b19 1a, different in genome-wide synonymous positions.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/a3939d6b3049467ea33a3ffff5b20280
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