BrtB is an O-alkylating enzyme that generates fatty acid-bartoloside esters

O-alkylation of carboxylates by alkyl halides has only been observed transiently in enzymatic processes. Here, the authors show a carboxylate alkylating enzyme, BrtB, that catalyzes C-O bond formation between free fatty acids and secondary alkyl chlorides.

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Auteurs principaux: João P. A. Reis, Sandra A. C. Figueiredo, Maria Lígia Sousa, Pedro N. Leão
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/a39484d669af4d91a489e9af1c3336c4
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Résumé:O-alkylation of carboxylates by alkyl halides has only been observed transiently in enzymatic processes. Here, the authors show a carboxylate alkylating enzyme, BrtB, that catalyzes C-O bond formation between free fatty acids and secondary alkyl chlorides.