The Gathering Storm: Is Untreatable Typhoid Fever on the Way?

ABSTRACT Klemm et al. (mBio 9:e00105-18, 2018, https://doi.org/10.1128/mBio.00105-18) present comprehensive antibiotic sensitivity patterns and genomic sequence data on Salmonella enterica serovar Typhi blood culture isolates from typhoid fever cases during an epidemic in Pakistan. Microbiologic and...

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Autores principales:	Myron M. Levine, Raphael Simon
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	ceftriaxone resistance chloramphenicol typhoid fever Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a3951e495c76465f95f211b7162f1527
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spelling	oai:doaj.org-article:a3951e495c76465f95f211b7162f15272021-11-15T15:53:27ZThe Gathering Storm: Is Untreatable Typhoid Fever on the Way?10.1128/mBio.00482-182150-7511https://doaj.org/article/a3951e495c76465f95f211b7162f15272018-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00482-18https://doaj.org/toc/2150-7511ABSTRACT Klemm et al. (mBio 9:e00105-18, 2018, https://doi.org/10.1128/mBio.00105-18) present comprehensive antibiotic sensitivity patterns and genomic sequence data on Salmonella enterica serovar Typhi blood culture isolates from typhoid fever cases during an epidemic in Pakistan. Microbiologic and genomic data pinpoint the identities and locations of the antimicrobial resistance genes and the outbreak strain’s lineage. They propose that Salmonella enterica serovar Typhi be added to the list of bacterial pathogens of public health importance that have become extensively drug resistant (XDR). This paper portends possible dire scenarios for typhoid fever control if XDR strains disseminate globally. Since the outbreak strain is of the H58 haplotype, known for its ability to spread worldwide and displace endemic S. Typhi, this concern is well-founded. The report of Klemm et al. forewarns the global community to address control of typhoid fever more aggressively through prevention, should therapeutic options disappear. This Commentary frames the Klemm et al. findings within a historic perspective.Myron M. LevineRaphael SimonAmerican Society for Microbiologyarticleceftriaxone resistancechloramphenicoltyphoid feverMicrobiologyQR1-502ENmBio, Vol 9, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ceftriaxone resistance chloramphenicol typhoid fever Microbiology QR1-502
spellingShingle	ceftriaxone resistance chloramphenicol typhoid fever Microbiology QR1-502 Myron M. Levine Raphael Simon The Gathering Storm: Is Untreatable Typhoid Fever on the Way?
description	ABSTRACT Klemm et al. (mBio 9:e00105-18, 2018, https://doi.org/10.1128/mBio.00105-18) present comprehensive antibiotic sensitivity patterns and genomic sequence data on Salmonella enterica serovar Typhi blood culture isolates from typhoid fever cases during an epidemic in Pakistan. Microbiologic and genomic data pinpoint the identities and locations of the antimicrobial resistance genes and the outbreak strain’s lineage. They propose that Salmonella enterica serovar Typhi be added to the list of bacterial pathogens of public health importance that have become extensively drug resistant (XDR). This paper portends possible dire scenarios for typhoid fever control if XDR strains disseminate globally. Since the outbreak strain is of the H58 haplotype, known for its ability to spread worldwide and displace endemic S. Typhi, this concern is well-founded. The report of Klemm et al. forewarns the global community to address control of typhoid fever more aggressively through prevention, should therapeutic options disappear. This Commentary frames the Klemm et al. findings within a historic perspective.
format	article
author	Myron M. Levine Raphael Simon
author_facet	Myron M. Levine Raphael Simon
author_sort	Myron M. Levine
title	The Gathering Storm: Is Untreatable Typhoid Fever on the Way?
title_short	The Gathering Storm: Is Untreatable Typhoid Fever on the Way?
title_full	The Gathering Storm: Is Untreatable Typhoid Fever on the Way?
title_fullStr	The Gathering Storm: Is Untreatable Typhoid Fever on the Way?
title_full_unstemmed	The Gathering Storm: Is Untreatable Typhoid Fever on the Way?
title_sort	gathering storm: is untreatable typhoid fever on the way?
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/a3951e495c76465f95f211b7162f1527
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The Gathering Storm: Is Untreatable Typhoid Fever on the Way?

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