lncRNA-ZFAS1 promotes the progression of endometrial carcinoma by targeting miR-34b to regulate VEGFA expression

Zinc finger nuclear transcription factor, X-box binding 1-type containing 1 antisense RNA 1 (ZFAS1) functions as an oncogenic long noncoding RNA (lncRNA) to promote proliferation and metastasis of endometrial carcinoma cell; however, the underlying mechanism has not been fully understood. First, RT-...

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Autores principales:	Zhu Hongli, Cheng Qihui, Cai Hong
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	zfas1 mir-34b vegfa endometrial carcinoma proliferation Medicine R
Acceso en línea:	https://doaj.org/article/a3957d28bd92464ba4608d9cb8700a43
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spelling	oai:doaj.org-article:a3957d28bd92464ba4608d9cb8700a432021-12-05T14:10:55ZlncRNA-ZFAS1 promotes the progression of endometrial carcinoma by targeting miR-34b to regulate VEGFA expression2391-546310.1515/med-2021-0362https://doaj.org/article/a3957d28bd92464ba4608d9cb8700a432021-10-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0362https://doaj.org/toc/2391-5463Zinc finger nuclear transcription factor, X-box binding 1-type containing 1 antisense RNA 1 (ZFAS1) functions as an oncogenic long noncoding RNA (lncRNA) to promote proliferation and metastasis of endometrial carcinoma cell; however, the underlying mechanism has not been fully understood. First, RT-qPCR analysis of endometrial carcinoma tissues and cells showed that ZFAS1 was enriched in endometrial carcinoma tissues and cells. miR-34b was reduced in endometrial carcinoma and suggested negative correlation with ZFAS1 in endometrial carcinoma. Second, functional assays demonstrated that siRNA-mediated silence of ZFAS1 suppressed endometrial carcinoma cell proliferation and metastasis. Third, ZFAS1 bind to miR-34b and negatively regulate expression of miR-34b in endometrial carcinoma cells. miR-34b also bind to and negatively regulate expression of vascular endothelial growth factor A (VEGFA) in endometrial carcinoma cells. Lastly, knockdown of miR-34b counteracted with the suppressive effects of ZFAS1 silence on endometrial carcinoma cell proliferation and metastasis. In conclusion, lncRNA ZFAS1 functioned as an oncogene to promote endometrial carcinoma cell proliferation and metastasis through miR-34b/VEGFA axis.Zhu HongliCheng QihuiCai HongDe Gruyterarticlezfas1mir-34bvegfaendometrial carcinomaproliferationMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1472-1481 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	zfas1 mir-34b vegfa endometrial carcinoma proliferation Medicine R
spellingShingle	zfas1 mir-34b vegfa endometrial carcinoma proliferation Medicine R Zhu Hongli Cheng Qihui Cai Hong lncRNA-ZFAS1 promotes the progression of endometrial carcinoma by targeting miR-34b to regulate VEGFA expression
description	Zinc finger nuclear transcription factor, X-box binding 1-type containing 1 antisense RNA 1 (ZFAS1) functions as an oncogenic long noncoding RNA (lncRNA) to promote proliferation and metastasis of endometrial carcinoma cell; however, the underlying mechanism has not been fully understood. First, RT-qPCR analysis of endometrial carcinoma tissues and cells showed that ZFAS1 was enriched in endometrial carcinoma tissues and cells. miR-34b was reduced in endometrial carcinoma and suggested negative correlation with ZFAS1 in endometrial carcinoma. Second, functional assays demonstrated that siRNA-mediated silence of ZFAS1 suppressed endometrial carcinoma cell proliferation and metastasis. Third, ZFAS1 bind to miR-34b and negatively regulate expression of miR-34b in endometrial carcinoma cells. miR-34b also bind to and negatively regulate expression of vascular endothelial growth factor A (VEGFA) in endometrial carcinoma cells. Lastly, knockdown of miR-34b counteracted with the suppressive effects of ZFAS1 silence on endometrial carcinoma cell proliferation and metastasis. In conclusion, lncRNA ZFAS1 functioned as an oncogene to promote endometrial carcinoma cell proliferation and metastasis through miR-34b/VEGFA axis.
format	article
author	Zhu Hongli Cheng Qihui Cai Hong
author_facet	Zhu Hongli Cheng Qihui Cai Hong
author_sort	Zhu Hongli
title	lncRNA-ZFAS1 promotes the progression of endometrial carcinoma by targeting miR-34b to regulate VEGFA expression
title_short	lncRNA-ZFAS1 promotes the progression of endometrial carcinoma by targeting miR-34b to regulate VEGFA expression
title_full	lncRNA-ZFAS1 promotes the progression of endometrial carcinoma by targeting miR-34b to regulate VEGFA expression
title_fullStr	lncRNA-ZFAS1 promotes the progression of endometrial carcinoma by targeting miR-34b to regulate VEGFA expression
title_full_unstemmed	lncRNA-ZFAS1 promotes the progression of endometrial carcinoma by targeting miR-34b to regulate VEGFA expression
title_sort	lncrna-zfas1 promotes the progression of endometrial carcinoma by targeting mir-34b to regulate vegfa expression
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/a3957d28bd92464ba4608d9cb8700a43
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lncRNA-ZFAS1 promotes the progression of endometrial carcinoma by targeting miR-34b to regulate VEGFA expression

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