TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease
TDP-43 inclusions are observed in Alzheimer’s disease. Here the authors show that TDP-43 interacts with amyloid-β and inhibits fibrillization in vitro and exacerbates Alzheimer’s disease pathology in animal models.
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Nature Portfolio
2020
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oai:doaj.org-article:a3987a249bec4a6a993488d9681fbc132021-12-02T13:57:33ZTDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease10.1038/s41467-020-19786-72041-1723https://doaj.org/article/a3987a249bec4a6a993488d9681fbc132020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19786-7https://doaj.org/toc/2041-1723TDP-43 inclusions are observed in Alzheimer’s disease. Here the authors show that TDP-43 interacts with amyloid-β and inhibits fibrillization in vitro and exacerbates Alzheimer’s disease pathology in animal models.Yao-Hsiang ShihLing-Hsien TuTing-Yu ChangKiruthika GanesanWei-Wei ChangPao-Sheng ChangYu-Sheng FangYeh-Tung LinLee-Way JinYun-Ru ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yao-Hsiang Shih Ling-Hsien Tu Ting-Yu Chang Kiruthika Ganesan Wei-Wei Chang Pao-Sheng Chang Yu-Sheng Fang Yeh-Tung Lin Lee-Way Jin Yun-Ru Chen TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease |
| description |
TDP-43 inclusions are observed in Alzheimer’s disease. Here the authors show that TDP-43 interacts with amyloid-β and inhibits fibrillization in vitro and exacerbates Alzheimer’s disease pathology in animal models. |
| format |
article |
| author |
Yao-Hsiang Shih Ling-Hsien Tu Ting-Yu Chang Kiruthika Ganesan Wei-Wei Chang Pao-Sheng Chang Yu-Sheng Fang Yeh-Tung Lin Lee-Way Jin Yun-Ru Chen |
| author_facet |
Yao-Hsiang Shih Ling-Hsien Tu Ting-Yu Chang Kiruthika Ganesan Wei-Wei Chang Pao-Sheng Chang Yu-Sheng Fang Yeh-Tung Lin Lee-Way Jin Yun-Ru Chen |
| author_sort |
Yao-Hsiang Shih |
| title |
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease |
| title_short |
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease |
| title_full |
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease |
| title_fullStr |
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease |
| title_full_unstemmed |
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease |
| title_sort |
tdp-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of alzheimer’s disease |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/a3987a249bec4a6a993488d9681fbc13 |
| work_keys_str_mv |
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| _version_ |
1718392337837588480 |