Mechanisms Underlying Hox-Mediated Transcriptional Outcomes

Metazoans differentially express multiple Hox transcription factors to specify diverse cell fates along the developing anterior-posterior axis. Two challenges arise when trying to understand how the Hox transcription factors regulate the required target genes for morphogenesis: First, how does each...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Brittany Cain, Brian Gebelein
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Hox transcription factor chromatin accessibility cis-regulatory modules (CRMs) protein-protein interaction Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a39a6c53f32948629abdae6a3fd06b87
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a39a6c53f32948629abdae6a3fd06b87
record_format	dspace
spelling	oai:doaj.org-article:a39a6c53f32948629abdae6a3fd06b872021-11-16T05:38:36ZMechanisms Underlying Hox-Mediated Transcriptional Outcomes2296-634X10.3389/fcell.2021.787339https://doaj.org/article/a39a6c53f32948629abdae6a3fd06b872021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.787339/fullhttps://doaj.org/toc/2296-634XMetazoans differentially express multiple Hox transcription factors to specify diverse cell fates along the developing anterior-posterior axis. Two challenges arise when trying to understand how the Hox transcription factors regulate the required target genes for morphogenesis: First, how does each Hox factor differ from one another to accurately activate and repress target genes required for the formation of distinct segment and regional identities? Second, how can a Hox factor that is broadly expressed in many tissues within a segment impact the development of specific organs by regulating target genes in a cell type-specific manner? In this review, we highlight how recent genomic, interactome, and cis-regulatory studies are providing new insights into answering these two questions. Collectively, these studies suggest that Hox factors may differentially modify the chromatin of gene targets as well as utilize numerous interactions with additional co-activators, co-repressors, and sequence-specific transcription factors to achieve accurate segment and cell type-specific transcriptional outcomes.Brittany CainBrian GebeleinBrian GebeleinFrontiers Media S.A.articleHoxtranscription factorchromatin accessibilitycis-regulatory modules (CRMs)protein-protein interactionBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hox transcription factor chromatin accessibility cis-regulatory modules (CRMs) protein-protein interaction Biology (General) QH301-705.5
spellingShingle	Hox transcription factor chromatin accessibility cis-regulatory modules (CRMs) protein-protein interaction Biology (General) QH301-705.5 Brittany Cain Brian Gebelein Brian Gebelein Mechanisms Underlying Hox-Mediated Transcriptional Outcomes
description	Metazoans differentially express multiple Hox transcription factors to specify diverse cell fates along the developing anterior-posterior axis. Two challenges arise when trying to understand how the Hox transcription factors regulate the required target genes for morphogenesis: First, how does each Hox factor differ from one another to accurately activate and repress target genes required for the formation of distinct segment and regional identities? Second, how can a Hox factor that is broadly expressed in many tissues within a segment impact the development of specific organs by regulating target genes in a cell type-specific manner? In this review, we highlight how recent genomic, interactome, and cis-regulatory studies are providing new insights into answering these two questions. Collectively, these studies suggest that Hox factors may differentially modify the chromatin of gene targets as well as utilize numerous interactions with additional co-activators, co-repressors, and sequence-specific transcription factors to achieve accurate segment and cell type-specific transcriptional outcomes.
format	article
author	Brittany Cain Brian Gebelein Brian Gebelein
author_facet	Brittany Cain Brian Gebelein Brian Gebelein
author_sort	Brittany Cain
title	Mechanisms Underlying Hox-Mediated Transcriptional Outcomes
title_short	Mechanisms Underlying Hox-Mediated Transcriptional Outcomes
title_full	Mechanisms Underlying Hox-Mediated Transcriptional Outcomes
title_fullStr	Mechanisms Underlying Hox-Mediated Transcriptional Outcomes
title_full_unstemmed	Mechanisms Underlying Hox-Mediated Transcriptional Outcomes
title_sort	mechanisms underlying hox-mediated transcriptional outcomes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a39a6c53f32948629abdae6a3fd06b87
work_keys_str_mv	AT brittanycain mechanismsunderlyinghoxmediatedtranscriptionaloutcomes AT briangebelein mechanismsunderlyinghoxmediatedtranscriptionaloutcomes AT briangebelein mechanismsunderlyinghoxmediatedtranscriptionaloutcomes
_version_	1718426685990240256

Mechanisms Underlying Hox-Mediated Transcriptional Outcomes

Ejemplares similares