Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics

The prefrontal cortex (PFC) is thought to orchestrate cognitive dynamics. However, in tests of bistable visual perception, no direct evidence supporting such presumable causal roles of the PFC has been reported except for a recent work. Here, using a novel brain-state-dependent neural stimulation sy...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Takamitsu Watanabe
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	energy landscape analysis bistable perception EEG TMS human Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a39b231d51314ef2930d54df5d4bc878
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a39b231d51314ef2930d54df5d4bc878
record_format	dspace
spelling	oai:doaj.org-article:a39b231d51314ef2930d54df5d4bc8782021-11-30T08:00:33ZCausal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics10.7554/eLife.690792050-084Xe69079https://doaj.org/article/a39b231d51314ef2930d54df5d4bc8782021-10-01T00:00:00Zhttps://elifesciences.org/articles/69079https://doaj.org/toc/2050-084XThe prefrontal cortex (PFC) is thought to orchestrate cognitive dynamics. However, in tests of bistable visual perception, no direct evidence supporting such presumable causal roles of the PFC has been reported except for a recent work. Here, using a novel brain-state-dependent neural stimulation system, we identified causal effects on percept dynamics in three PFC activities—right frontal eye fields, dorsolateral PFC (DLPFC), and inferior frontal cortex (IFC). The causality is behaviourally detectable only when we track brain state dynamics and modulate the PFC activity in brain-state-/state-history-dependent manners. The behavioural effects are underpinned by transient neural changes in the brain state dynamics, and such neural effects are quantitatively explainable by structural transformations of the hypothetical energy landscapes. Moreover, these findings indicate distinct functions of the three PFC areas: in particular, the DLPFC enhances the integration of two PFC-active brain states, whereas IFC promotes the functional segregation between them. This work resolves the controversy over the PFC roles in spontaneous perceptual switching and underlines brain state dynamics in fine investigations of brain-behaviour causality.Takamitsu WatanabeeLife Sciences Publications Ltdarticleenergy landscape analysisbistable perceptionEEGTMShumanMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	energy landscape analysis bistable perception EEG TMS human Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	energy landscape analysis bistable perception EEG TMS human Medicine R Science Q Biology (General) QH301-705.5 Takamitsu Watanabe Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics
description	The prefrontal cortex (PFC) is thought to orchestrate cognitive dynamics. However, in tests of bistable visual perception, no direct evidence supporting such presumable causal roles of the PFC has been reported except for a recent work. Here, using a novel brain-state-dependent neural stimulation system, we identified causal effects on percept dynamics in three PFC activities—right frontal eye fields, dorsolateral PFC (DLPFC), and inferior frontal cortex (IFC). The causality is behaviourally detectable only when we track brain state dynamics and modulate the PFC activity in brain-state-/state-history-dependent manners. The behavioural effects are underpinned by transient neural changes in the brain state dynamics, and such neural effects are quantitatively explainable by structural transformations of the hypothetical energy landscapes. Moreover, these findings indicate distinct functions of the three PFC areas: in particular, the DLPFC enhances the integration of two PFC-active brain states, whereas IFC promotes the functional segregation between them. This work resolves the controversy over the PFC roles in spontaneous perceptual switching and underlines brain state dynamics in fine investigations of brain-behaviour causality.
format	article
author	Takamitsu Watanabe
author_facet	Takamitsu Watanabe
author_sort	Takamitsu Watanabe
title	Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics
title_short	Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics
title_full	Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics
title_fullStr	Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics
title_full_unstemmed	Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics
title_sort	causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/a39b231d51314ef2930d54df5d4bc878
work_keys_str_mv	AT takamitsuwatanabe causalrolesofprefrontalcortexduringspontaneousperceptualswitchingaredeterminedbybrainstatedynamics
_version_	1718406766128005120

Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics

Ejemplares similares