Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Joern Pezoldt et al. analyze mouse spleen fibroblasts using single cell RNA sequencing, revealing 11 distinct clusters of fibroblastic cells or subtypes. Their results collectively provide further insight into the transcriptional identities of splenic fibroblasts and innate immune signatures of dist...

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Autores principales:	Joern Pezoldt, Carolin Wiechers, Florian Erhard, Ulfert Rand, Tanja Bulat, Michael Beckstette, Andrea Brendolan, Jochen Huehn, Ulrich Kalinke, Mathias Mueller, Birgit Strobl, Bart Deplancke, Luka Čičin-Šain, Katarzyna M. Sitnik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a39bfb883b614159a6fc0d605a03133d
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spelling	oai:doaj.org-article:a39bfb883b614159a6fc0d605a03133d2021-12-05T12:08:19ZSingle-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection10.1038/s42003-021-02882-92399-3642https://doaj.org/article/a39bfb883b614159a6fc0d605a03133d2021-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02882-9https://doaj.org/toc/2399-3642Joern Pezoldt et al. analyze mouse spleen fibroblasts using single cell RNA sequencing, revealing 11 distinct clusters of fibroblastic cells or subtypes. Their results collectively provide further insight into the transcriptional identities of splenic fibroblasts and innate immune signatures of distinct stromal compartments.Joern PezoldtCarolin WiechersFlorian ErhardUlfert RandTanja BulatMichael BeckstetteAndrea BrendolanJochen HuehnUlrich KalinkeMathias MuellerBirgit StroblBart DeplanckeLuka Čičin-ŠainKatarzyna M. SitnikNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Joern Pezoldt Carolin Wiechers Florian Erhard Ulfert Rand Tanja Bulat Michael Beckstette Andrea Brendolan Jochen Huehn Ulrich Kalinke Mathias Mueller Birgit Strobl Bart Deplancke Luka Čičin-Šain Katarzyna M. Sitnik Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
description	Joern Pezoldt et al. analyze mouse spleen fibroblasts using single cell RNA sequencing, revealing 11 distinct clusters of fibroblastic cells or subtypes. Their results collectively provide further insight into the transcriptional identities of splenic fibroblasts and innate immune signatures of distinct stromal compartments.
format	article
author	Joern Pezoldt Carolin Wiechers Florian Erhard Ulfert Rand Tanja Bulat Michael Beckstette Andrea Brendolan Jochen Huehn Ulrich Kalinke Mathias Mueller Birgit Strobl Bart Deplancke Luka Čičin-Šain Katarzyna M. Sitnik
author_facet	Joern Pezoldt Carolin Wiechers Florian Erhard Ulfert Rand Tanja Bulat Michael Beckstette Andrea Brendolan Jochen Huehn Ulrich Kalinke Mathias Mueller Birgit Strobl Bart Deplancke Luka Čičin-Šain Katarzyna M. Sitnik
author_sort	Joern Pezoldt
title	Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
title_short	Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
title_full	Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
title_fullStr	Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
title_full_unstemmed	Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
title_sort	single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a39bfb883b614159a6fc0d605a03133d
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Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

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