Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice
Characterized as a complex of extracellular DNA fibers and granule proteins, neutrophil extracellular traps (NETs) are generated specifically by neutrophils which play a critical role in host defense and immune regulation. NETs have been initially found crucial for neutrophil anti-microbial function...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:a3a10e0062f94148b1bb531deed939fb2021-11-19T05:01:28ZNeutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice2234-943X10.3389/fonc.2021.766636https://doaj.org/article/a3a10e0062f94148b1bb531deed939fb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.766636/fullhttps://doaj.org/toc/2234-943XCharacterized as a complex of extracellular DNA fibers and granule proteins, neutrophil extracellular traps (NETs) are generated specifically by neutrophils which play a critical role in host defense and immune regulation. NETs have been initially found crucial for neutrophil anti-microbial function. Recent studies suggest that NETs are involved in tumorigenesis and cancer progression. However, the function of NETs in cancer remains unclear, which might be due to the variation of research models and the heterogeneity of cancers. Although most of malignant tumors have similar biological behaviors, significant differences indeed exist in various systems. Malignant tumors of the digestive system cause the most incidence and mortality of cancer worldwide. In this review, we would focus on research developments on NETs in digestive cancers to provide insights on their role in digestive cancer progression and future research directions.Yuxin ChenYuxin ChenLulu HanLulu HanLulu HanXiaoyan QiuXiaoyan QiuGang WangGang WangGang WangJunnian ZhengJunnian ZhengFrontiers Media S.A.articleneutrophil extracellular trapcancerdigestive systemimmunitytargeted therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
neutrophil extracellular trap cancer digestive system immunity targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
neutrophil extracellular trap cancer digestive system immunity targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yuxin Chen Yuxin Chen Lulu Han Lulu Han Lulu Han Xiaoyan Qiu Xiaoyan Qiu Gang Wang Gang Wang Gang Wang Junnian Zheng Junnian Zheng Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice |
| description |
Characterized as a complex of extracellular DNA fibers and granule proteins, neutrophil extracellular traps (NETs) are generated specifically by neutrophils which play a critical role in host defense and immune regulation. NETs have been initially found crucial for neutrophil anti-microbial function. Recent studies suggest that NETs are involved in tumorigenesis and cancer progression. However, the function of NETs in cancer remains unclear, which might be due to the variation of research models and the heterogeneity of cancers. Although most of malignant tumors have similar biological behaviors, significant differences indeed exist in various systems. Malignant tumors of the digestive system cause the most incidence and mortality of cancer worldwide. In this review, we would focus on research developments on NETs in digestive cancers to provide insights on their role in digestive cancer progression and future research directions. |
| format |
article |
| author |
Yuxin Chen Yuxin Chen Lulu Han Lulu Han Lulu Han Xiaoyan Qiu Xiaoyan Qiu Gang Wang Gang Wang Gang Wang Junnian Zheng Junnian Zheng |
| author_facet |
Yuxin Chen Yuxin Chen Lulu Han Lulu Han Lulu Han Xiaoyan Qiu Xiaoyan Qiu Gang Wang Gang Wang Gang Wang Junnian Zheng Junnian Zheng |
| author_sort |
Yuxin Chen |
| title |
Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice |
| title_short |
Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice |
| title_full |
Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice |
| title_fullStr |
Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice |
| title_full_unstemmed |
Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice |
| title_sort |
neutrophil extracellular traps in digestive cancers: warrior or accomplice |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/a3a10e0062f94148b1bb531deed939fb |
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