Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness

Abstract To investigate the effects of heart rate (HR), left ventricular ejection time (LVET) and wave reflection on arterial stiffness as assessed by pulse wave velocity (PWV), a pulse wave propagation simulation system (PWPSim) based on the transmission line model of the arterial tree was develope...

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Autores principales:	Hanguang Xiao, Mark Butlin, Isabella Tan, Alberto Avolio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3a13be541f24d328755a6c285128768
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spelling	oai:doaj.org-article:a3a13be541f24d328755a6c2851287682021-12-02T11:52:32ZEffects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness10.1038/s41598-017-05807-x2045-2322https://doaj.org/article/a3a13be541f24d328755a6c2851287682017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05807-xhttps://doaj.org/toc/2045-2322Abstract To investigate the effects of heart rate (HR), left ventricular ejection time (LVET) and wave reflection on arterial stiffness as assessed by pulse wave velocity (PWV), a pulse wave propagation simulation system (PWPSim) based on the transmission line model of the arterial tree was developed and was applied to investigate pulse wave propagation. HR, LVET, arterial elastic modulus and peripheral resistance were increased from 60 to 100 beats per minute (bpm), 0.1 to 0.45 seconds, 0.5 to 1.5 times and 0.5 to 1.5 times of the normal value, respectively. Carotid-femoral PWV (cfPWV) and brachial-ankle PWV (baPWV) were calculated by intersecting tangent method (cfPWVtan and baPWVtan), maximum slope (cfPWVmax and baPWVmax), and using the Moens-Korteweg equation ( $${\bf{cfPW}}{{\bf{V}}}_{{{\bf{c}}}_{{\bf{0}}}}$$ cfPW V c 0 and $${\bf{baPW}}{{\bf{V}}}_{{{\bf{c}}}_{{\bf{0}}}}$$ baPW V c 0 ). Results showed cfPWV and baPWV increased significantly with arterial elastic modulus but did not increase with HR when using a constant elastic modulus. However there were significant LVET dependencies of cfPWVtan and baPWVtan (0.17 ± 0.13 and 0.17 ± 0.08 m/s per 50 ms), and low peripheral resistance dependencies of cfPWVtan, cfPWVmax, baPWVtan and baPWVmax (0.04 ± 0.01, 0.06 ± 0.04, 0.06 ± 0.03 and 0.09 ± 0.07 m/s per 10% peripheral resistance), respectively. This study demonstrated that LVET dominates the effect on calculated PWV compared to HR and peripheral resistance when arterial elastic modulus is constant.Hanguang XiaoMark ButlinIsabella TanAlberto AvolioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hanguang Xiao Mark Butlin Isabella Tan Alberto Avolio Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness
description	Abstract To investigate the effects of heart rate (HR), left ventricular ejection time (LVET) and wave reflection on arterial stiffness as assessed by pulse wave velocity (PWV), a pulse wave propagation simulation system (PWPSim) based on the transmission line model of the arterial tree was developed and was applied to investigate pulse wave propagation. HR, LVET, arterial elastic modulus and peripheral resistance were increased from 60 to 100 beats per minute (bpm), 0.1 to 0.45 seconds, 0.5 to 1.5 times and 0.5 to 1.5 times of the normal value, respectively. Carotid-femoral PWV (cfPWV) and brachial-ankle PWV (baPWV) were calculated by intersecting tangent method (cfPWVtan and baPWVtan), maximum slope (cfPWVmax and baPWVmax), and using the Moens-Korteweg equation ( $${\bf{cfPW}}{{\bf{V}}}_{{{\bf{c}}}_{{\bf{0}}}}$$ cfPW V c 0 and $${\bf{baPW}}{{\bf{V}}}_{{{\bf{c}}}_{{\bf{0}}}}$$ baPW V c 0 ). Results showed cfPWV and baPWV increased significantly with arterial elastic modulus but did not increase with HR when using a constant elastic modulus. However there were significant LVET dependencies of cfPWVtan and baPWVtan (0.17 ± 0.13 and 0.17 ± 0.08 m/s per 50 ms), and low peripheral resistance dependencies of cfPWVtan, cfPWVmax, baPWVtan and baPWVmax (0.04 ± 0.01, 0.06 ± 0.04, 0.06 ± 0.03 and 0.09 ± 0.07 m/s per 10% peripheral resistance), respectively. This study demonstrated that LVET dominates the effect on calculated PWV compared to HR and peripheral resistance when arterial elastic modulus is constant.
format	article
author	Hanguang Xiao Mark Butlin Isabella Tan Alberto Avolio
author_facet	Hanguang Xiao Mark Butlin Isabella Tan Alberto Avolio
author_sort	Hanguang Xiao
title	Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness
title_short	Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness
title_full	Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness
title_fullStr	Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness
title_full_unstemmed	Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness
title_sort	effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a3a13be541f24d328755a6c285128768
work_keys_str_mv	AT hanguangxiao effectsofcardiactimingandperipheralresistanceonmeasurementofpulsewavevelocityforassessmentofarterialstiffness AT markbutlin effectsofcardiactimingandperipheralresistanceonmeasurementofpulsewavevelocityforassessmentofarterialstiffness AT isabellatan effectsofcardiactimingandperipheralresistanceonmeasurementofpulsewavevelocityforassessmentofarterialstiffness AT albertoavolio effectsofcardiactimingandperipheralresistanceonmeasurementofpulsewavevelocityforassessmentofarterialstiffness
_version_	1718395001667321856

Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness

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