An engineered oncolytic virus expressing PD-L1 inhibitors activates tumor neoantigen-specific T cell responses

An engineered oncolytic virus expressing PD-L1 inhibitors activates tumor neoantigen-specific T cell responses

Oncolytic viruses can activate tumor neoantigen-specific T cell responses. However, PD-L1 upregulation on tumor cells and immune cells leads to tumor resistance to this immunotherapy approach. Here, the authors develop an oncolytic virus which expresses both a PD-L1 inhibitor and GM-CSF which allows...

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Bibliographic Details
Main Authors: Guan Wang, Xi Kang, Katherine S. Chen, Tiffany Jehng, Lindsey Jones, Jie Chen, Xue F. Huang, Si-Yi Chen
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/a3a3521c2e584a13a47f5027ebb743e3
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