<named-content content-type="genus-species">Ehrlichia chaffeensis</named-content> TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival

<named-content content-type="genus-species">Ehrlichia chaffeensis</named-content> TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival

ABSTRACT Ehrlichia chaffeensis preferentially targets mononuclear phagocytes and survives through a strategy of subverting innate immune defenses, but the mechanisms are unknown. We have shown E. chaffeensis type 1 secreted tandem repeat protein (TRP) effectors are involved in diverse molecular path...

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Bibliographic Details
Main Authors: Taslima T. Lina, Paige S. Dunphy, Tian Luo, Jere W. McBride
Format: article
Language:EN
Published: American Society for Microbiology 2016
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/a3a41c4f93ec4b9f9e3f5f7d348d0abb
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