Emerging role of brain metastases in the prognosis of breast cancer patients

Amanda Hambrecht1,2, Rahul Jandial2, Josh Neman21Department of Biology, University of Southern California; 2Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, CA, USAAbstract: Cancer starts with one rogue cell. Through mutations and genomic alterations, the...

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Autores principales:	Hambrecht A, Jandial R, Neman J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a3a4588218cf42918b22e7ac7f0a93ca
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id	oai:doaj.org-article:a3a4588218cf42918b22e7ac7f0a93ca
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spelling	oai:doaj.org-article:a3a4588218cf42918b22e7ac7f0a93ca2021-12-02T04:30:56ZEmerging role of brain metastases in the prognosis of breast cancer patients1179-1314https://doaj.org/article/a3a4588218cf42918b22e7ac7f0a93ca2011-08-01T00:00:00Zhttp://www.dovepress.com/emerging-role-of-brain-metastases-in-the-prognosis-of-breast-cancer-pa-a8049https://doaj.org/toc/1179-1314Amanda Hambrecht1,2, Rahul Jandial2, Josh Neman21Department of Biology, University of Southern California; 2Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, CA, USAAbstract: Cancer starts with one rogue cell. Through mutations and genomic alterations, the cell acquires specific and stem cell-like characteristics necessary for invasion of a distant organ and ultimately metastasis. Metastatic brain cancer is a particularly formidable disease because of its poor prognosis and the highly resistant nature of the tumor to chemotherapy. Although several types of primary tumors have a tendency to metastasize to the brain, the incidence of brain metastases has increased dramatically in some subsets of breast cancer patients. Several conventional treatments are available, but success is limited and often short-lived. Given that no standard treatment options exist, there is a significant need to investigate the biology of these clinically recalcitrant tumors. Keywords: metastasis, breast cancer, blood-brain barrier, epithelial-mesenchymal transition, mesenchymal-epithelial transitionHambrecht AJandial RNeman JDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2011, Iss default, Pp 79-91 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hambrecht A Jandial R Neman J Emerging role of brain metastases in the prognosis of breast cancer patients
description	Amanda Hambrecht1,2, Rahul Jandial2, Josh Neman21Department of Biology, University of Southern California; 2Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, CA, USAAbstract: Cancer starts with one rogue cell. Through mutations and genomic alterations, the cell acquires specific and stem cell-like characteristics necessary for invasion of a distant organ and ultimately metastasis. Metastatic brain cancer is a particularly formidable disease because of its poor prognosis and the highly resistant nature of the tumor to chemotherapy. Although several types of primary tumors have a tendency to metastasize to the brain, the incidence of brain metastases has increased dramatically in some subsets of breast cancer patients. Several conventional treatments are available, but success is limited and often short-lived. Given that no standard treatment options exist, there is a significant need to investigate the biology of these clinically recalcitrant tumors. Keywords: metastasis, breast cancer, blood-brain barrier, epithelial-mesenchymal transition, mesenchymal-epithelial transition
format	article
author	Hambrecht A Jandial R Neman J
author_facet	Hambrecht A Jandial R Neman J
author_sort	Hambrecht A
title	Emerging role of brain metastases in the prognosis of breast cancer patients
title_short	Emerging role of brain metastases in the prognosis of breast cancer patients
title_full	Emerging role of brain metastases in the prognosis of breast cancer patients
title_fullStr	Emerging role of brain metastases in the prognosis of breast cancer patients
title_full_unstemmed	Emerging role of brain metastases in the prognosis of breast cancer patients
title_sort	emerging role of brain metastases in the prognosis of breast cancer patients
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/a3a4588218cf42918b22e7ac7f0a93ca
work_keys_str_mv	AT hambrechta emergingroleofbrainmetastasesintheprognosisofbreastcancerpatients AT jandialr emergingroleofbrainmetastasesintheprognosisofbreastcancerpatients AT nemanj emergingroleofbrainmetastasesintheprognosisofbreastcancerpatients
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Emerging role of brain metastases in the prognosis of breast cancer patients

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