Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors

One big threat from influenza A viruses (IAVs) is that novel viruses emerge from mutation alongside reassortment. Some of them have gained the capability to transmit into human from the avian reservoir. Understanding the molecular events and the involved factors in breaking the cross-species barrier...

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Autores principales:	Miaomiao Zhang, Mingbin Liu, Shimeng Bai, Chen Zhao, Zejun Li, Jianqing Xu, Xiaoyan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	influenza A virus host specificity pathogenesis host factors PB2 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a3a5825221cd42bd8cf83fac15fd736b
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spelling	oai:doaj.org-article:a3a5825221cd42bd8cf83fac15fd736b2021-11-05T14:47:58ZInfluenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors1664-302X10.3389/fmicb.2021.777885https://doaj.org/article/a3a5825221cd42bd8cf83fac15fd736b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.777885/fullhttps://doaj.org/toc/1664-302XOne big threat from influenza A viruses (IAVs) is that novel viruses emerge from mutation alongside reassortment. Some of them have gained the capability to transmit into human from the avian reservoir. Understanding the molecular events and the involved factors in breaking the cross-species barrier holds important implication for the surveillance and prevention of potential influenza outbreaks. In this review, we summarize recent progresses, including several ground-breaking findings, in how the interaction between host and viral factors, exemplified by the PB2 subunit of the influenza virus RNA polymerase co-opting host ANP32 protein to facilitate transcription and replication of the viral genome, shapes the evolution of IAVs from host specificity to cross-species infection.Miaomiao ZhangMiaomiao ZhangMingbin LiuShimeng BaiChen ZhaoZejun LiJianqing XuXiaoyan ZhangFrontiers Media S.A.articleinfluenza A virushost specificitypathogenesishost factorsPB2MicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	influenza A virus host specificity pathogenesis host factors PB2 Microbiology QR1-502
spellingShingle	influenza A virus host specificity pathogenesis host factors PB2 Microbiology QR1-502 Miaomiao Zhang Miaomiao Zhang Mingbin Liu Shimeng Bai Chen Zhao Zejun Li Jianqing Xu Xiaoyan Zhang Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors
description	One big threat from influenza A viruses (IAVs) is that novel viruses emerge from mutation alongside reassortment. Some of them have gained the capability to transmit into human from the avian reservoir. Understanding the molecular events and the involved factors in breaking the cross-species barrier holds important implication for the surveillance and prevention of potential influenza outbreaks. In this review, we summarize recent progresses, including several ground-breaking findings, in how the interaction between host and viral factors, exemplified by the PB2 subunit of the influenza virus RNA polymerase co-opting host ANP32 protein to facilitate transcription and replication of the viral genome, shapes the evolution of IAVs from host specificity to cross-species infection.
format	article
author	Miaomiao Zhang Miaomiao Zhang Mingbin Liu Shimeng Bai Chen Zhao Zejun Li Jianqing Xu Xiaoyan Zhang
author_facet	Miaomiao Zhang Miaomiao Zhang Mingbin Liu Shimeng Bai Chen Zhao Zejun Li Jianqing Xu Xiaoyan Zhang
author_sort	Miaomiao Zhang
title	Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors
title_short	Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors
title_full	Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors
title_fullStr	Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors
title_full_unstemmed	Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors
title_sort	influenza a virus–host specificity: an ongoing cross-talk between viral and host factors
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a3a5825221cd42bd8cf83fac15fd736b
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Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors

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