Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

ABSTRACT Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals. Coronavirus RNA synthesis is thought to be associated with replication organelles (ROs) consisting of modified endoplasmic...

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Bibliographic Details

Main Authors:	Diede Oudshoorn, Kevin Rijs, Ronald W. A. L. Limpens, Kevin Groen, Abraham J. Koster, Eric J. Snijder, Marjolein Kikkert, Montserrat Bárcena
Format:	article
Language:	EN
Published:	American Society for Microbiology 2017
Subjects:	convoluted membranes electron tomography membrane structure nidoviruses nonstructural proteins replication complex Microbiology QR1-502
Online Access:	https://doaj.org/article/a3a7cf2cc99549698cbfbe0f6767b044
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