Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights

Natural bioactive compounds derived from plant-based products are known for their biological immunomodulatory activities. They possess systemic pleiotropic effects, minimal side effects, and very low toxicities. Plant-based bioactive compounds have tremendous potential as natural therapeutic entitie...

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Autores principales:	Vani Gangwar, Amar Garg, Karan Lomore, Kalyani Korla, Shruthi S. Bhat, Raghavendra P. Rao, Mohamed Rafiq, Rajesh Kumawath, Babu V. Uddagiri, Venkatesh V. Kareenhalli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Apigenin Quercetin Betulinic acid Oleanolic acid β-Sitosterol inflammation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a3a914a55b4046af826199bc5606b98e
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spelling	oai:doaj.org-article:a3a914a55b4046af826199bc5606b98e2021-11-25T16:48:31ZImmunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights10.3390/biomedicines91115222227-9059https://doaj.org/article/a3a914a55b4046af826199bc5606b98e2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1522https://doaj.org/toc/2227-9059Natural bioactive compounds derived from plant-based products are known for their biological immunomodulatory activities. They possess systemic pleiotropic effects, minimal side effects, and very low toxicities. Plant-based bioactive compounds have tremendous potential as natural therapeutic entities against various disease conditions and act as anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-viral, anti-tumour, anti-allergic, neuroprotective, and cardioprotective agents. A herbal formulation extract including five biologically active compounds: Apigenin, Quercetin, Betulinic acid, Oleanolic acid, and β-Sitosterol can impart several immunomodulatory effects. In this review, we systematically present the impact of these compounds on important molecular signaling pathways, including inflammation, immunity, redox metabolism, neuroinflammation, neutropenia, cell growth, apoptosis, and cell cycle. The review corroborates the beneficial effect of these compounds and shows considerable potential to be used as a safer, more cost-effective treatment for several diseases by affecting the major nodal points of various stimulatory pathways.Vani GangwarAmar GargKaran LomoreKalyani KorlaShruthi S. BhatRaghavendra P. RaoMohamed RafiqRajesh KumawathBabu V. UddagiriVenkatesh V. KareenhalliMDPI AGarticleApigeninQuercetinBetulinic acidOleanolic acidβ-SitosterolinflammationBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1522, p 1522 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Apigenin Quercetin Betulinic acid Oleanolic acid β-Sitosterol inflammation Biology (General) QH301-705.5
spellingShingle	Apigenin Quercetin Betulinic acid Oleanolic acid β-Sitosterol inflammation Biology (General) QH301-705.5 Vani Gangwar Amar Garg Karan Lomore Kalyani Korla Shruthi S. Bhat Raghavendra P. Rao Mohamed Rafiq Rajesh Kumawath Babu V. Uddagiri Venkatesh V. Kareenhalli Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights
description	Natural bioactive compounds derived from plant-based products are known for their biological immunomodulatory activities. They possess systemic pleiotropic effects, minimal side effects, and very low toxicities. Plant-based bioactive compounds have tremendous potential as natural therapeutic entities against various disease conditions and act as anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-viral, anti-tumour, anti-allergic, neuroprotective, and cardioprotective agents. A herbal formulation extract including five biologically active compounds: Apigenin, Quercetin, Betulinic acid, Oleanolic acid, and β-Sitosterol can impart several immunomodulatory effects. In this review, we systematically present the impact of these compounds on important molecular signaling pathways, including inflammation, immunity, redox metabolism, neuroinflammation, neutropenia, cell growth, apoptosis, and cell cycle. The review corroborates the beneficial effect of these compounds and shows considerable potential to be used as a safer, more cost-effective treatment for several diseases by affecting the major nodal points of various stimulatory pathways.
format	article
author	Vani Gangwar Amar Garg Karan Lomore Kalyani Korla Shruthi S. Bhat Raghavendra P. Rao Mohamed Rafiq Rajesh Kumawath Babu V. Uddagiri Venkatesh V. Kareenhalli
author_facet	Vani Gangwar Amar Garg Karan Lomore Kalyani Korla Shruthi S. Bhat Raghavendra P. Rao Mohamed Rafiq Rajesh Kumawath Babu V. Uddagiri Venkatesh V. Kareenhalli
author_sort	Vani Gangwar
title	Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights
title_short	Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights
title_full	Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights
title_fullStr	Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights
title_full_unstemmed	Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights
title_sort	immunomodulatory effects of a concoction of natural bioactive compounds—mechanistic insights
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a3a914a55b4046af826199bc5606b98e
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Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights

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