Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis

Waskiewicz et al. identify functionally important and evolutionarily conserved residues of ATM/ATR via data mining and a functional genetic analysis, finding that loss of the intrinsic kinase activity occurs infrequently in carcinogenesis. This study provides insights into the genotype-phenotype rel...

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Autores principales:	Erik Waskiewicz, Michalis Vasiliou, Isaac Corcoles-Saez, Rita S. Cha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a3ab37abd19345cbb306b4a4b5e50121
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spelling	oai:doaj.org-article:a3ab37abd19345cbb306b4a4b5e501212021-12-02T11:39:38ZCancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis10.1038/s42003-021-01884-x2399-3642https://doaj.org/article/a3ab37abd19345cbb306b4a4b5e501212021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01884-xhttps://doaj.org/toc/2399-3642Waskiewicz et al. identify functionally important and evolutionarily conserved residues of ATM/ATR via data mining and a functional genetic analysis, finding that loss of the intrinsic kinase activity occurs infrequently in carcinogenesis. This study provides insights into the genotype-phenotype relationships in ATM/ATR and their cancer-associated variants.Erik WaskiewiczMichalis VasiliouIsaac Corcoles-SaezRita S. ChaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Erik Waskiewicz Michalis Vasiliou Isaac Corcoles-Saez Rita S. Cha Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
description	Waskiewicz et al. identify functionally important and evolutionarily conserved residues of ATM/ATR via data mining and a functional genetic analysis, finding that loss of the intrinsic kinase activity occurs infrequently in carcinogenesis. This study provides insights into the genotype-phenotype relationships in ATM/ATR and their cancer-associated variants.
format	article
author	Erik Waskiewicz Michalis Vasiliou Isaac Corcoles-Saez Rita S. Cha
author_facet	Erik Waskiewicz Michalis Vasiliou Isaac Corcoles-Saez Rita S. Cha
author_sort	Erik Waskiewicz
title	Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
title_short	Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
title_full	Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
title_fullStr	Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
title_full_unstemmed	Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
title_sort	cancer genome datamining and functional genetic analysis implicate mechanisms of atm/atr dysfunction underpinning carcinogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3ab37abd19345cbb306b4a4b5e50121
work_keys_str_mv	AT erikwaskiewicz cancergenomedataminingandfunctionalgeneticanalysisimplicatemechanismsofatmatrdysfunctionunderpinningcarcinogenesis AT michalisvasiliou cancergenomedataminingandfunctionalgeneticanalysisimplicatemechanismsofatmatrdysfunctionunderpinningcarcinogenesis AT isaaccorcolessaez cancergenomedataminingandfunctionalgeneticanalysisimplicatemechanismsofatmatrdysfunctionunderpinningcarcinogenesis AT ritascha cancergenomedataminingandfunctionalgeneticanalysisimplicatemechanismsofatmatrdysfunctionunderpinningcarcinogenesis
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Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis

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