CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS

Abstract. This study demonstrates ability of carbon monoxide to trigger mitochondrial pathway of apoptosis induction of Jurcat cells. We have shown that proapoptotic action of carbon monoxide is coupled to permeabilization of cellular mitochondrial membranes. Imbalance in Bcl-2 family of regulatory...

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Autores principales:	E. G. Starikova, L. A. Tashireva, E. V. Beldiagina, O. A. Vasilieva, V. V. Novitsky, N. V. Ryazantseva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	carbon monoxide apoptosis mitochondia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a3ada925b35a4c20860c40247081ddf3
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spelling	oai:doaj.org-article:a3ada925b35a4c20860c40247081ddf32021-11-18T08:03:41ZCARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS1563-06252313-741X10.15789/1563-0625-2012-4-5-353-358https://doaj.org/article/a3ada925b35a4c20860c40247081ddf32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/527https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. This study demonstrates ability of carbon monoxide to trigger mitochondrial pathway of apoptosis induction of Jurcat cells. We have shown that proapoptotic action of carbon monoxide is coupled to permeabilization of cellular mitochondrial membranes. Imbalance in Bcl-2 family of regulatory proteins may be considered among possible reasons of the membrane pore formation. We have shown downregulated cl-2 and Bcl-xl mRNA expression and decreased levels of antiapoptotic proteins, along wih decreased mRNA expression and increase of Bad proapototic protein level in Jurkat cells following incubation with 50 μm of CORM-2, a carbon monoxide donor.E. G. StarikovaL. A. TashirevaE. V. BeldiaginaO. A. VasilievaV. V. NovitskyN. V. RyazantsevaSPb RAACIarticlecarbon monoxideapoptosismitochondiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 353-358 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	carbon monoxide apoptosis mitochondia Immunologic diseases. Allergy RC581-607
spellingShingle	carbon monoxide apoptosis mitochondia Immunologic diseases. Allergy RC581-607 E. G. Starikova L. A. Tashireva E. V. Beldiagina O. A. Vasilieva V. V. Novitsky N. V. Ryazantseva CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS
description	Abstract. This study demonstrates ability of carbon monoxide to trigger mitochondrial pathway of apoptosis induction of Jurcat cells. We have shown that proapoptotic action of carbon monoxide is coupled to permeabilization of cellular mitochondrial membranes. Imbalance in Bcl-2 family of regulatory proteins may be considered among possible reasons of the membrane pore formation. We have shown downregulated cl-2 and Bcl-xl mRNA expression and decreased levels of antiapoptotic proteins, along wih decreased mRNA expression and increase of Bad proapototic protein level in Jurkat cells following incubation with 50 μm of CORM-2, a carbon monoxide donor.
format	article
author	E. G. Starikova L. A. Tashireva E. V. Beldiagina O. A. Vasilieva V. V. Novitsky N. V. Ryazantseva
author_facet	E. G. Starikova L. A. Tashireva E. V. Beldiagina O. A. Vasilieva V. V. Novitsky N. V. Ryazantseva
author_sort	E. G. Starikova
title	CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS
title_short	CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS
title_full	CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS
title_fullStr	CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS
title_full_unstemmed	CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS
title_sort	carbon monoxide: its role in mitochondrial pathway of apoptosis induction in jurkat cancer cells
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a3ada925b35a4c20860c40247081ddf3
work_keys_str_mv	AT egstarikova carbonmonoxideitsroleinmitochondrialpathwayofapoptosisinductioninjurkatcancercells AT latashireva carbonmonoxideitsroleinmitochondrialpathwayofapoptosisinductioninjurkatcancercells AT evbeldiagina carbonmonoxideitsroleinmitochondrialpathwayofapoptosisinductioninjurkatcancercells AT oavasilieva carbonmonoxideitsroleinmitochondrialpathwayofapoptosisinductioninjurkatcancercells AT vvnovitsky carbonmonoxideitsroleinmitochondrialpathwayofapoptosisinductioninjurkatcancercells AT nvryazantseva carbonmonoxideitsroleinmitochondrialpathwayofapoptosisinductioninjurkatcancercells
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CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS

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