Unusual Mammalian Sex Determination Systems: A Cabinet of Curiosities

Therian mammals have among the oldest and most conserved sex-determining systems known to date. Any deviation from the standard XX/XY mammalian sex chromosome constitution usually leads to sterility or poor fertility, due to the high differentiation and specialization of the X and Y chromosomes. Nev...

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Autores principales:	Paul A. Saunders, Frédéric Veyrunes
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mammals rodents sex determination sex chromosomes meiosis Genetics QH426-470
Acceso en línea:	https://doaj.org/article/a3b1e2bff4094dfcb7201fa84975c923
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spelling	oai:doaj.org-article:a3b1e2bff4094dfcb7201fa84975c9232021-11-25T17:41:45ZUnusual Mammalian Sex Determination Systems: A Cabinet of Curiosities10.3390/genes121117702073-4425https://doaj.org/article/a3b1e2bff4094dfcb7201fa84975c9232021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1770https://doaj.org/toc/2073-4425Therian mammals have among the oldest and most conserved sex-determining systems known to date. Any deviation from the standard XX/XY mammalian sex chromosome constitution usually leads to sterility or poor fertility, due to the high differentiation and specialization of the X and Y chromosomes. Nevertheless, a handful of rodents harbor so-called unusual sex-determining systems. While in some species, fertile XY females are found, some others have completely lost their Y chromosome. These atypical species have fascinated researchers for over 60 years, and constitute unique natural models for the study of fundamental processes involved in sex determination in mammals and vertebrates. In this article, we review current knowledge of these species, discuss their similarities and differences, and attempt to expose how the study of their exceptional sex-determining systems can further our understanding of general processes involved in sex chromosome and sex determination evolution.Paul A. SaundersFrédéric VeyrunesMDPI AGarticlemammalsrodentssex determinationsex chromosomesmeiosisGeneticsQH426-470ENGenes, Vol 12, Iss 1770, p 1770 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mammals rodents sex determination sex chromosomes meiosis Genetics QH426-470
spellingShingle	mammals rodents sex determination sex chromosomes meiosis Genetics QH426-470 Paul A. Saunders Frédéric Veyrunes Unusual Mammalian Sex Determination Systems: A Cabinet of Curiosities
description	Therian mammals have among the oldest and most conserved sex-determining systems known to date. Any deviation from the standard XX/XY mammalian sex chromosome constitution usually leads to sterility or poor fertility, due to the high differentiation and specialization of the X and Y chromosomes. Nevertheless, a handful of rodents harbor so-called unusual sex-determining systems. While in some species, fertile XY females are found, some others have completely lost their Y chromosome. These atypical species have fascinated researchers for over 60 years, and constitute unique natural models for the study of fundamental processes involved in sex determination in mammals and vertebrates. In this article, we review current knowledge of these species, discuss their similarities and differences, and attempt to expose how the study of their exceptional sex-determining systems can further our understanding of general processes involved in sex chromosome and sex determination evolution.
format	article
author	Paul A. Saunders Frédéric Veyrunes
author_facet	Paul A. Saunders Frédéric Veyrunes
author_sort	Paul A. Saunders
title	Unusual Mammalian Sex Determination Systems: A Cabinet of Curiosities
title_short	Unusual Mammalian Sex Determination Systems: A Cabinet of Curiosities
title_full	Unusual Mammalian Sex Determination Systems: A Cabinet of Curiosities
title_fullStr	Unusual Mammalian Sex Determination Systems: A Cabinet of Curiosities
title_full_unstemmed	Unusual Mammalian Sex Determination Systems: A Cabinet of Curiosities
title_sort	unusual mammalian sex determination systems: a cabinet of curiosities
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a3b1e2bff4094dfcb7201fa84975c923
work_keys_str_mv	AT paulasaunders unusualmammaliansexdeterminationsystemsacabinetofcuriosities AT fredericveyrunes unusualmammaliansexdeterminationsystemsacabinetofcuriosities
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Unusual Mammalian Sex Determination Systems: A Cabinet of Curiosities

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