Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury

Traumatic brain injury (TBI) is linked to several pathologies. The blood-brain barrier (BBB) breakdown is considered to be one of the initial changes. Further, the microenvironmental alteration following TBI-induced BBB breakdown can be multi-scaled, constant, and dramatic. The microenvironmental va...

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Autores principales:	Yue Hu, Weiwei Tao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	traumatic brain injury blood-brain barrier microenvironment edema inflammation toxic substances Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/a3b37875dc1249118ecaf829a5ab42a8
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spelling	oai:doaj.org-article:a3b37875dc1249118ecaf829a5ab42a82021-12-01T08:06:35ZMicroenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury1662-509910.3389/fnmol.2021.750810https://doaj.org/article/a3b37875dc1249118ecaf829a5ab42a82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.750810/fullhttps://doaj.org/toc/1662-5099Traumatic brain injury (TBI) is linked to several pathologies. The blood-brain barrier (BBB) breakdown is considered to be one of the initial changes. Further, the microenvironmental alteration following TBI-induced BBB breakdown can be multi-scaled, constant, and dramatic. The microenvironmental variations after disruption of BBB includes several pathological changes, such as cerebral blood flow (CBF) alteration, brain edema, cerebral metabolism imbalances, and accumulation of inflammatory molecules. The modulation of the microenvironment presents attractive targets for TBI recovery, such as reducing toxic substances, inhibiting inflammation, and promoting neurogenesis. Herein, we briefly review the pathological alterations of the microenvironmental changes following BBB breakdown and outline potential interventions for TBI recovery based on microenvironmental modulation.Yue HuWeiwei TaoWeiwei TaoFrontiers Media S.A.articletraumatic brain injuryblood-brain barriermicroenvironmentedemainflammationtoxic substancesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	traumatic brain injury blood-brain barrier microenvironment edema inflammation toxic substances Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	traumatic brain injury blood-brain barrier microenvironment edema inflammation toxic substances Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Yue Hu Weiwei Tao Weiwei Tao Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury
description	Traumatic brain injury (TBI) is linked to several pathologies. The blood-brain barrier (BBB) breakdown is considered to be one of the initial changes. Further, the microenvironmental alteration following TBI-induced BBB breakdown can be multi-scaled, constant, and dramatic. The microenvironmental variations after disruption of BBB includes several pathological changes, such as cerebral blood flow (CBF) alteration, brain edema, cerebral metabolism imbalances, and accumulation of inflammatory molecules. The modulation of the microenvironment presents attractive targets for TBI recovery, such as reducing toxic substances, inhibiting inflammation, and promoting neurogenesis. Herein, we briefly review the pathological alterations of the microenvironmental changes following BBB breakdown and outline potential interventions for TBI recovery based on microenvironmental modulation.
format	article
author	Yue Hu Weiwei Tao Weiwei Tao
author_facet	Yue Hu Weiwei Tao Weiwei Tao
author_sort	Yue Hu
title	Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury
title_short	Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury
title_full	Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury
title_fullStr	Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury
title_full_unstemmed	Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury
title_sort	microenvironmental variations after blood-brain barrier breakdown in traumatic brain injury
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a3b37875dc1249118ecaf829a5ab42a8
work_keys_str_mv	AT yuehu microenvironmentalvariationsafterbloodbrainbarrierbreakdownintraumaticbraininjury AT weiweitao microenvironmentalvariationsafterbloodbrainbarrierbreakdownintraumaticbraininjury AT weiweitao microenvironmentalvariationsafterbloodbrainbarrierbreakdownintraumaticbraininjury
_version_	1718405430868180992

Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury

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