Effects of platelet-rich plasma on healing of sphincteroplasty: An experiment in rabbit model

Background: Inability to manage of stool release, fecal incontinence, is a condition with sever negative effects on the patients’ quality of life. Use of platelet-rich plasma in healing of anal sphincter might improve outcomes. The current study investigated the healing effects of PRP application af...

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Autores principales:	Ahmad Izadpanah, Habibollah Nikzad Jamnani, Alireza Safarpour, Ahad Izadpanah, Seyed Mohammad Kazem Tadayon
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2019
Materias:	anal sphincter healing platelet-rich plasma sphincterotomy sphincteroplasty Medicine R
Acceso en línea:	https://doaj.org/article/a3b3b32057264bebb37b57e52667c09d
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spelling	oai:doaj.org-article:a3b3b32057264bebb37b57e52667c09d2021-11-14T08:42:24ZEffects of platelet-rich plasma on healing of sphincteroplasty: An experiment in rabbit model2783-2430https://doaj.org/article/a3b3b32057264bebb37b57e52667c09d2019-09-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45847_106caa06b5757d3abab9b2efbb3d3ecf.pdfhttps://doaj.org/toc/2783-2430Background: Inability to manage of stool release, fecal incontinence, is a condition with sever negative effects on the patients’ quality of life. Use of platelet-rich plasma in healing of anal sphincter might improve outcomes. The current study investigated the healing effects of PRP application after surgical repair of sphincter in rabbits as an animal model for human studies. Methods: Twenty-four New Zealand rabbits were randomly allocated into 4 groups based on the time of healing at one and three weeks after sphincteroplasty and using of PRP. Sphincterotomy and then sphincteroplasty were performed in all animals and autologous PRP was prepared and used as dose as 0.5 ml per animal. The healing scores of sphincter were compared between four groups using histological scoring system. Results: The histological healing score in PRP used group was significantly higher than not PRP used group after one week (18.6 ± 0.8 vs. 13.0 ± 1.8 respectively, P = 0.01) but no significant difference was detected between healing score of PRP used and not PRP used groups after three weeks (19.0 ± 0.0 vs. 18.5 ± 0.8 respectively, P = 0.17).Conclusion: Our findings indicated that although PRP had an accelerator role in wound healing of sphincter repair, but it has not significant effects over time especially after 3 weeks.Ahmad IzadpanahHabibollah Nikzad JamnaniAlireza SafarpourAhad IzadpanahSeyed Mohammad Kazem TadayonShiraz University of Medical Sciencesarticleanal sphincterhealingplatelet-rich plasmasphincterotomysphincteroplastyMedicineRENIranian Journal of Colorectal Research, Vol 7, Iss 3, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	anal sphincter healing platelet-rich plasma sphincterotomy sphincteroplasty Medicine R
spellingShingle	anal sphincter healing platelet-rich plasma sphincterotomy sphincteroplasty Medicine R Ahmad Izadpanah Habibollah Nikzad Jamnani Alireza Safarpour Ahad Izadpanah Seyed Mohammad Kazem Tadayon Effects of platelet-rich plasma on healing of sphincteroplasty: An experiment in rabbit model
description	Background: Inability to manage of stool release, fecal incontinence, is a condition with sever negative effects on the patients’ quality of life. Use of platelet-rich plasma in healing of anal sphincter might improve outcomes. The current study investigated the healing effects of PRP application after surgical repair of sphincter in rabbits as an animal model for human studies. Methods: Twenty-four New Zealand rabbits were randomly allocated into 4 groups based on the time of healing at one and three weeks after sphincteroplasty and using of PRP. Sphincterotomy and then sphincteroplasty were performed in all animals and autologous PRP was prepared and used as dose as 0.5 ml per animal. The healing scores of sphincter were compared between four groups using histological scoring system. Results: The histological healing score in PRP used group was significantly higher than not PRP used group after one week (18.6 ± 0.8 vs. 13.0 ± 1.8 respectively, P = 0.01) but no significant difference was detected between healing score of PRP used and not PRP used groups after three weeks (19.0 ± 0.0 vs. 18.5 ± 0.8 respectively, P = 0.17).Conclusion: Our findings indicated that although PRP had an accelerator role in wound healing of sphincter repair, but it has not significant effects over time especially after 3 weeks.
format	article
author	Ahmad Izadpanah Habibollah Nikzad Jamnani Alireza Safarpour Ahad Izadpanah Seyed Mohammad Kazem Tadayon
author_facet	Ahmad Izadpanah Habibollah Nikzad Jamnani Alireza Safarpour Ahad Izadpanah Seyed Mohammad Kazem Tadayon
author_sort	Ahmad Izadpanah
title	Effects of platelet-rich plasma on healing of sphincteroplasty: An experiment in rabbit model
title_short	Effects of platelet-rich plasma on healing of sphincteroplasty: An experiment in rabbit model
title_full	Effects of platelet-rich plasma on healing of sphincteroplasty: An experiment in rabbit model
title_fullStr	Effects of platelet-rich plasma on healing of sphincteroplasty: An experiment in rabbit model
title_full_unstemmed	Effects of platelet-rich plasma on healing of sphincteroplasty: An experiment in rabbit model
title_sort	effects of platelet-rich plasma on healing of sphincteroplasty: an experiment in rabbit model
publisher	Shiraz University of Medical Sciences
publishDate	2019
url	https://doaj.org/article/a3b3b32057264bebb37b57e52667c09d
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Effects of platelet-rich plasma on healing of sphincteroplasty: An experiment in rabbit model

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