In vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography

Abstract The purpose of the present study was to investigate the vascular flow density (VD) of macular superficial (SCP), deep capillary plexus (DCP), and choriocapillaris and the size of the foveal avascular zone (FAZ) area in healthy children using optical coherence tomography angiography (OCTA)....

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Autores principales:	Zhengwei Zhang, Xiaoli Huang, Xiaomei Meng, Tiantian Chen, Yan Gu, Yan Wu, Zhifeng Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3b4167304f74553a43d11d5f86e70c6
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spelling	oai:doaj.org-article:a3b4167304f74553a43d11d5f86e70c62021-12-02T11:52:43ZIn vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography10.1038/s41598-017-08174-92045-2322https://doaj.org/article/a3b4167304f74553a43d11d5f86e70c62017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08174-9https://doaj.org/toc/2045-2322Abstract The purpose of the present study was to investigate the vascular flow density (VD) of macular superficial (SCP), deep capillary plexus (DCP), and choriocapillaris and the size of the foveal avascular zone (FAZ) area in healthy children using optical coherence tomography angiography (OCTA). The potential associations of age, sex, intraocular pressure, body mass index, spherical equivalent, and axial length with OCTA parameters were also investigated. A total of 75 eyes from 75 healthy children were included for analysis, with the mean age 11.51 ± 1.91 years (range, 8–16 years). At the level of the SCP, mean VD and mean FAZ area were, respectively, 54.29 ± 2.25% and 0.290 ± 0.109 mm2. At the level of the DCP and choriocapillaris, mean VD were 60.19 ± 1.76% and 66.58 ± 1.33%, respectively. After adjustment on the signal strength index, there was no significant correlation between age and all OCTA parameters. Intra-observer repeatability was 0.91, 0.82, and 0.88 in the SCP, DCP and choriocapillaris, respectively. In healthy eyes of children, only sex has a significant influence on the FAZ area. OCTA may provide a noninvasive and reliable approach for evaluating macular perfusion in children, although sex-related variations should be considered.Zhengwei ZhangXiaoli HuangXiaomei MengTiantian ChenYan GuYan WuZhifeng WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhengwei Zhang Xiaoli Huang Xiaomei Meng Tiantian Chen Yan Gu Yan Wu Zhifeng Wu In vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography
description	Abstract The purpose of the present study was to investigate the vascular flow density (VD) of macular superficial (SCP), deep capillary plexus (DCP), and choriocapillaris and the size of the foveal avascular zone (FAZ) area in healthy children using optical coherence tomography angiography (OCTA). The potential associations of age, sex, intraocular pressure, body mass index, spherical equivalent, and axial length with OCTA parameters were also investigated. A total of 75 eyes from 75 healthy children were included for analysis, with the mean age 11.51 ± 1.91 years (range, 8–16 years). At the level of the SCP, mean VD and mean FAZ area were, respectively, 54.29 ± 2.25% and 0.290 ± 0.109 mm2. At the level of the DCP and choriocapillaris, mean VD were 60.19 ± 1.76% and 66.58 ± 1.33%, respectively. After adjustment on the signal strength index, there was no significant correlation between age and all OCTA parameters. Intra-observer repeatability was 0.91, 0.82, and 0.88 in the SCP, DCP and choriocapillaris, respectively. In healthy eyes of children, only sex has a significant influence on the FAZ area. OCTA may provide a noninvasive and reliable approach for evaluating macular perfusion in children, although sex-related variations should be considered.
format	article
author	Zhengwei Zhang Xiaoli Huang Xiaomei Meng Tiantian Chen Yan Gu Yan Wu Zhifeng Wu
author_facet	Zhengwei Zhang Xiaoli Huang Xiaomei Meng Tiantian Chen Yan Gu Yan Wu Zhifeng Wu
author_sort	Zhengwei Zhang
title	In vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography
title_short	In vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography
title_full	In vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography
title_fullStr	In vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography
title_full_unstemmed	In vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography
title_sort	in vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a3b4167304f74553a43d11d5f86e70c6
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In vivo assessment of macula in eyes of healthy children 8 to 16 years old using optical coherence tomography angiography

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