JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise

Abstract Organismal development is precisely regulated by a sequence of gene functions even in the presence of biological noise. However, it is difficult to evaluate the effect of noise in vivo, and the mechanisms by which noise is filtered during development are largely unknown. To identify the noi...

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Autores principales:	Yoshitaro Tanaka, Tetsuo Yasugi, Masaharu Nagayama, Makoto Sato, Shin-Ichiro Ei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3b59b24c3d243a0929ab790bad6cd20
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spelling	oai:doaj.org-article:a3b59b24c3d243a0929ab790bad6cd202021-12-02T11:40:17ZJAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise10.1038/s41598-018-30929-12045-2322https://doaj.org/article/a3b59b24c3d243a0929ab790bad6cd202018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30929-1https://doaj.org/toc/2045-2322Abstract Organismal development is precisely regulated by a sequence of gene functions even in the presence of biological noise. However, it is difficult to evaluate the effect of noise in vivo, and the mechanisms by which noise is filtered during development are largely unknown. To identify the noise-canceling mechanism, we used the fly visual system, in which the timing of differentiation of neural stem cells is spatio-temporally ordered. Our mathematical model predicts that JAK/STAT signaling contributes to noise canceling to guarantee the robust progression of the differentiation wave in silico. We further demonstrate that the suppression of JAK/STAT signaling causes stochastic and ectopic neural stem cell differentiation in vivo, suggesting an evolutionarily conserved function of JAK/STAT to regulate the robustness of stem cell differentiation.Yoshitaro TanakaTetsuo YasugiMasaharu NagayamaMakoto SatoShin-Ichiro EiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshitaro Tanaka Tetsuo Yasugi Masaharu Nagayama Makoto Sato Shin-Ichiro Ei JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise
description	Abstract Organismal development is precisely regulated by a sequence of gene functions even in the presence of biological noise. However, it is difficult to evaluate the effect of noise in vivo, and the mechanisms by which noise is filtered during development are largely unknown. To identify the noise-canceling mechanism, we used the fly visual system, in which the timing of differentiation of neural stem cells is spatio-temporally ordered. Our mathematical model predicts that JAK/STAT signaling contributes to noise canceling to guarantee the robust progression of the differentiation wave in silico. We further demonstrate that the suppression of JAK/STAT signaling causes stochastic and ectopic neural stem cell differentiation in vivo, suggesting an evolutionarily conserved function of JAK/STAT to regulate the robustness of stem cell differentiation.
format	article
author	Yoshitaro Tanaka Tetsuo Yasugi Masaharu Nagayama Makoto Sato Shin-Ichiro Ei
author_facet	Yoshitaro Tanaka Tetsuo Yasugi Masaharu Nagayama Makoto Sato Shin-Ichiro Ei
author_sort	Yoshitaro Tanaka
title	JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise
title_short	JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise
title_full	JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise
title_fullStr	JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise
title_full_unstemmed	JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise
title_sort	jak/stat guarantees robust neural stem cell differentiation by shutting off biological noise
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a3b59b24c3d243a0929ab790bad6cd20
work_keys_str_mv	AT yoshitarotanaka jakstatguaranteesrobustneuralstemcelldifferentiationbyshuttingoffbiologicalnoise AT tetsuoyasugi jakstatguaranteesrobustneuralstemcelldifferentiationbyshuttingoffbiologicalnoise AT masaharunagayama jakstatguaranteesrobustneuralstemcelldifferentiationbyshuttingoffbiologicalnoise AT makotosato jakstatguaranteesrobustneuralstemcelldifferentiationbyshuttingoffbiologicalnoise AT shinichiroei jakstatguaranteesrobustneuralstemcelldifferentiationbyshuttingoffbiologicalnoise
_version_	1718395663302000640

JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise

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