Human osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma

Abstract Plasma-treatment of oral implant biomaterials prior to clinical insertion is envisaged as a potential surface modification method for enhanced implant healing. To investigate a putative effect of plasma-functionalized implant biomaterials on oral tissue cells, this investigation examined th...

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Autores principales:	Kerstin Rabel, Ralf-Joachim Kohal, Thorsten Steinberg, Bernd Rolauffs, Erik Adolfsson, Brigitte Altmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3b632b291934316847d9fa66116df49
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spelling	oai:doaj.org-article:a3b632b291934316847d9fa66116df492021-12-02T19:02:35ZHuman osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma10.1038/s41598-021-96526-x2045-2322https://doaj.org/article/a3b632b291934316847d9fa66116df492021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96526-xhttps://doaj.org/toc/2045-2322Abstract Plasma-treatment of oral implant biomaterials prior to clinical insertion is envisaged as a potential surface modification method for enhanced implant healing. To investigate a putative effect of plasma-functionalized implant biomaterials on oral tissue cells, this investigation examined the response of alveolar bone osteoblasts and gingival fibroblasts to clinically established zirconia- and titanium-based implant surfaces for bone and soft tissue integration. The biomaterials were either functionalized with oxygen-plasma in a plasma-cleaner or left untreated as controls, and were characterized in terms of topography and wettability. For the biological evaluation, the cell adhesion, morphogenesis, metabolic activity and proliferation were examined, since these parameters are closely interconnected during cell-biomaterial interaction. The results revealed that plasma-functionalization increased implant surface wettability. The magnitude of this effect thereby depended on surface topography parameters and initial wettability of the biomaterials. Concerning the cell response, plasma-functionalization of smooth surfaces affected initial fibroblast morphogenesis, whereas osteoblast morphology on rough surfaces was mainly influenced by topography. The plasma- and topography-induced differential cell morphologies were however not strong enough to trigger a change in proliferation behaviour. Hence, the results indicate that oxygen plasma-functionalization represents a possible cytocompatible implant surface modification method which can be applied for tailoring implant surface wettability.Kerstin RabelRalf-Joachim KohalThorsten SteinbergBernd RolauffsErik AdolfssonBrigitte AltmannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kerstin Rabel Ralf-Joachim Kohal Thorsten Steinberg Bernd Rolauffs Erik Adolfsson Brigitte Altmann Human osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma
description	Abstract Plasma-treatment of oral implant biomaterials prior to clinical insertion is envisaged as a potential surface modification method for enhanced implant healing. To investigate a putative effect of plasma-functionalized implant biomaterials on oral tissue cells, this investigation examined the response of alveolar bone osteoblasts and gingival fibroblasts to clinically established zirconia- and titanium-based implant surfaces for bone and soft tissue integration. The biomaterials were either functionalized with oxygen-plasma in a plasma-cleaner or left untreated as controls, and were characterized in terms of topography and wettability. For the biological evaluation, the cell adhesion, morphogenesis, metabolic activity and proliferation were examined, since these parameters are closely interconnected during cell-biomaterial interaction. The results revealed that plasma-functionalization increased implant surface wettability. The magnitude of this effect thereby depended on surface topography parameters and initial wettability of the biomaterials. Concerning the cell response, plasma-functionalization of smooth surfaces affected initial fibroblast morphogenesis, whereas osteoblast morphology on rough surfaces was mainly influenced by topography. The plasma- and topography-induced differential cell morphologies were however not strong enough to trigger a change in proliferation behaviour. Hence, the results indicate that oxygen plasma-functionalization represents a possible cytocompatible implant surface modification method which can be applied for tailoring implant surface wettability.
format	article
author	Kerstin Rabel Ralf-Joachim Kohal Thorsten Steinberg Bernd Rolauffs Erik Adolfsson Brigitte Altmann
author_facet	Kerstin Rabel Ralf-Joachim Kohal Thorsten Steinberg Bernd Rolauffs Erik Adolfsson Brigitte Altmann
author_sort	Kerstin Rabel
title	Human osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma
title_short	Human osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma
title_full	Human osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma
title_fullStr	Human osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma
title_full_unstemmed	Human osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma
title_sort	human osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3b632b291934316847d9fa66116df49
work_keys_str_mv	AT kerstinrabel humanosteoblastandfibroblastresponsetooralimplantbiomaterialsfunctionalizedwithnonthermaloxygenplasma AT ralfjoachimkohal humanosteoblastandfibroblastresponsetooralimplantbiomaterialsfunctionalizedwithnonthermaloxygenplasma AT thorstensteinberg humanosteoblastandfibroblastresponsetooralimplantbiomaterialsfunctionalizedwithnonthermaloxygenplasma AT berndrolauffs humanosteoblastandfibroblastresponsetooralimplantbiomaterialsfunctionalizedwithnonthermaloxygenplasma AT erikadolfsson humanosteoblastandfibroblastresponsetooralimplantbiomaterialsfunctionalizedwithnonthermaloxygenplasma AT brigittealtmann humanosteoblastandfibroblastresponsetooralimplantbiomaterialsfunctionalizedwithnonthermaloxygenplasma
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Human osteoblast and fibroblast response to oral implant biomaterials functionalized with non-thermal oxygen plasma

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