Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review

Background: Children are susceptible to environmental contaminants and are at risk of developing diseases, more so if the exposure begins at an early age. Epidemiological studies have postulated the hypothesis of the fetal origin of disease, which is mediated by epigenetic changes. Epigenetic marks...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Isabel Alvarado-Cruz, Jorge A. Alegría-Torres, Nereida Montes-Castro, Octavio Jiménez-Garza, Betzabet Quintanilla-Vega
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2018
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/a3bc559b87cb4fdc8591ea6f4a750dd8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a3bc559b87cb4fdc8591ea6f4a750dd8
record_format	dspace
spelling	oai:doaj.org-article:a3bc559b87cb4fdc8591ea6f4a750dd82021-12-02T00:09:51ZEnvironmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review2214-999610.29024/aogh.909https://doaj.org/article/a3bc559b87cb4fdc8591ea6f4a750dd82018-07-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/909https://doaj.org/toc/2214-9996Background: Children are susceptible to environmental contaminants and are at risk of developing diseases, more so if the exposure begins at an early age. Epidemiological studies have postulated the hypothesis of the fetal origin of disease, which is mediated by epigenetic changes. Epigenetic marks are inheritable; they modulate the gene expression and can affect human health due to the presence of environmental factors. Objective: This review focuses on DNA-methylation and its association with environmental-related diseases in children. Methods: A search for studies related to DNA-methylation in children by pre- or post-natal environmental exposures was conducted, and those studies with appropriate designs and statistical analyses and evaluations of the exposure were selected. Findings: Prenatal and early life environmental factors, from diet to exposure to pollutants, have been associated with epigenetic changes, specifically DNA-methylation. Thus, maternal nutrition and smoking and exposure to air particulate matter, polycyclic aromatic hydrocarbons, arsenic, heavy metals, persistent organic pollutants, and some endocrine disrupters during pregnancy have been associated with genomic and gene-specific newborns’ DNA-methylation changes that have shown in some cases sex-specific patterns. In addition, these maternal factors may deregulate the placental DNA-methylation balance and could induce a fetal reprogramming and later-in-life diseases. Conclusions: Exposure to environmental pollutants during prenatal and early life can trigger epigenetic imbalances and eventually the development of diseases in children. The integration of epigenetic data should be considered in future risk assessments.Isabel Alvarado-CruzJorge A. Alegría-TorresNereida Montes-CastroOctavio Jiménez-GarzaBetzabet Quintanilla-VegaUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 84, Iss 2, Pp 212-224 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Isabel Alvarado-Cruz Jorge A. Alegría-Torres Nereida Montes-Castro Octavio Jiménez-Garza Betzabet Quintanilla-Vega Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review
description	Background: Children are susceptible to environmental contaminants and are at risk of developing diseases, more so if the exposure begins at an early age. Epidemiological studies have postulated the hypothesis of the fetal origin of disease, which is mediated by epigenetic changes. Epigenetic marks are inheritable; they modulate the gene expression and can affect human health due to the presence of environmental factors. Objective: This review focuses on DNA-methylation and its association with environmental-related diseases in children. Methods: A search for studies related to DNA-methylation in children by pre- or post-natal environmental exposures was conducted, and those studies with appropriate designs and statistical analyses and evaluations of the exposure were selected. Findings: Prenatal and early life environmental factors, from diet to exposure to pollutants, have been associated with epigenetic changes, specifically DNA-methylation. Thus, maternal nutrition and smoking and exposure to air particulate matter, polycyclic aromatic hydrocarbons, arsenic, heavy metals, persistent organic pollutants, and some endocrine disrupters during pregnancy have been associated with genomic and gene-specific newborns’ DNA-methylation changes that have shown in some cases sex-specific patterns. In addition, these maternal factors may deregulate the placental DNA-methylation balance and could induce a fetal reprogramming and later-in-life diseases. Conclusions: Exposure to environmental pollutants during prenatal and early life can trigger epigenetic imbalances and eventually the development of diseases in children. The integration of epigenetic data should be considered in future risk assessments.
format	article
author	Isabel Alvarado-Cruz Jorge A. Alegría-Torres Nereida Montes-Castro Octavio Jiménez-Garza Betzabet Quintanilla-Vega
author_facet	Isabel Alvarado-Cruz Jorge A. Alegría-Torres Nereida Montes-Castro Octavio Jiménez-Garza Betzabet Quintanilla-Vega
author_sort	Isabel Alvarado-Cruz
title	Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review
title_short	Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review
title_full	Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review
title_fullStr	Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review
title_full_unstemmed	Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review
title_sort	environmental epigenetic changes, as risk factors for the development of diseases in children: a systematic review
publisher	Ubiquity Press
publishDate	2018
url	https://doaj.org/article/a3bc559b87cb4fdc8591ea6f4a750dd8
work_keys_str_mv	AT isabelalvaradocruz environmentalepigeneticchangesasriskfactorsforthedevelopmentofdiseasesinchildrenasystematicreview AT jorgeaalegriatorres environmentalepigeneticchangesasriskfactorsforthedevelopmentofdiseasesinchildrenasystematicreview AT nereidamontescastro environmentalepigeneticchangesasriskfactorsforthedevelopmentofdiseasesinchildrenasystematicreview AT octaviojimenezgarza environmentalepigeneticchangesasriskfactorsforthedevelopmentofdiseasesinchildrenasystematicreview AT betzabetquintanillavega environmentalepigeneticchangesasriskfactorsforthedevelopmentofdiseasesinchildrenasystematicreview
_version_	1718403946140139520

Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review

Ejemplares similares