The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases
Over the past several decades, RNA modifications have rapidly emerged as an indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation at the sixth position of an adenine base in an RNA molecule, is the most prevalent RNA modification in both coding and noncoding RNAs....
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Frontiers Media S.A.
2021
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oai:doaj.org-article:a3bc61df73a14fdd86de5976334203432021-11-16T06:46:29ZThe Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases2296-634X10.3389/fcell.2021.755691https://doaj.org/article/a3bc61df73a14fdd86de5976334203432021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.755691/fullhttps://doaj.org/toc/2296-634XOver the past several decades, RNA modifications have rapidly emerged as an indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation at the sixth position of an adenine base in an RNA molecule, is the most prevalent RNA modification in both coding and noncoding RNAs. m6A has emerged as a crucial posttranscriptional regulator involved in both physiological and pathological processes. Based on accumulating evidence, m6A participates in the pathogenesis of immune-related diseases by regulating both innate and adaptive immune cells through various mechanisms. Autoimmune diseases are caused by a self-destructive immune response in the setting of genetic and environmental factors, and recent studies have discovered that m6A may play an essential role in the development of autoimmune diseases. In this review, we focus on the important role of m6A modification in biological functions and highlight its contributions to immune cells and the development of autoimmune diseases, thereby providing promising epitranscriptomic targets for preventing and treating autoimmune disorders.Yimeng WangLifang LiJiaqi LiBin ZhaoGan HuangXia LiZhiguo XieZhiguang ZhouFrontiers Media S.A.articleRNA modificationsN6-methyladenosineautoimmune disordersinnate immunityadaptive immunityBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
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DOAJ |
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DOAJ |
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RNA modifications N6-methyladenosine autoimmune disorders innate immunity adaptive immunity Biology (General) QH301-705.5 |
| spellingShingle |
RNA modifications N6-methyladenosine autoimmune disorders innate immunity adaptive immunity Biology (General) QH301-705.5 Yimeng Wang Lifang Li Jiaqi Li Bin Zhao Gan Huang Xia Li Zhiguo Xie Zhiguang Zhou The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases |
| description |
Over the past several decades, RNA modifications have rapidly emerged as an indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation at the sixth position of an adenine base in an RNA molecule, is the most prevalent RNA modification in both coding and noncoding RNAs. m6A has emerged as a crucial posttranscriptional regulator involved in both physiological and pathological processes. Based on accumulating evidence, m6A participates in the pathogenesis of immune-related diseases by regulating both innate and adaptive immune cells through various mechanisms. Autoimmune diseases are caused by a self-destructive immune response in the setting of genetic and environmental factors, and recent studies have discovered that m6A may play an essential role in the development of autoimmune diseases. In this review, we focus on the important role of m6A modification in biological functions and highlight its contributions to immune cells and the development of autoimmune diseases, thereby providing promising epitranscriptomic targets for preventing and treating autoimmune disorders. |
| format |
article |
| author |
Yimeng Wang Lifang Li Jiaqi Li Bin Zhao Gan Huang Xia Li Zhiguo Xie Zhiguang Zhou |
| author_facet |
Yimeng Wang Lifang Li Jiaqi Li Bin Zhao Gan Huang Xia Li Zhiguo Xie Zhiguang Zhou |
| author_sort |
Yimeng Wang |
| title |
The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases |
| title_short |
The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases |
| title_full |
The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases |
| title_fullStr |
The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases |
| title_full_unstemmed |
The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases |
| title_sort |
emerging role of m6a modification in regulating the immune system and autoimmune diseases |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/a3bc61df73a14fdd86de597633420343 |
| work_keys_str_mv |
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