Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation

Abstract We investigated differences in brain activation associated with cognitive fatigue between persons with traumatic brain injury (TBI) and healthy controls (HCs). Twenty-two participants with moderate-severe TBI and 20 HCs performed four blocks of a difficult working memory task and four block...

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Autores principales:	G. R. Wylie, E. Dobryakova, J. DeLuca, N. Chiaravalloti, K. Essad, H. Genova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3bd422f18b6474f85eedf7a8f458cb5
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spelling	oai:doaj.org-article:a3bd422f18b6474f85eedf7a8f458cb52021-12-02T16:06:54ZCognitive fatigue in individuals with traumatic brain injury is associated with caudate activation10.1038/s41598-017-08846-62045-2322https://doaj.org/article/a3bd422f18b6474f85eedf7a8f458cb52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08846-6https://doaj.org/toc/2045-2322Abstract We investigated differences in brain activation associated with cognitive fatigue between persons with traumatic brain injury (TBI) and healthy controls (HCs). Twenty-two participants with moderate-severe TBI and 20 HCs performed four blocks of a difficult working memory task and four blocks of a control task during fMRI imaging. Cognitive fatigue, assessed before and after each block, was used as a covariate to assess fatigue-related brain activation. The TBI group reported more fatigue than the HCs, though their performance was comparable. Regarding brain activation, the TBI group showed a Task X Fatigue interaction in the caudate tail resulting from a positive correlation between fatigue and brain activation for the difficult task and a negative relationship for the control task. The HC group showed the same Task X Fatigue interaction in the caudate head. Because we had prior hypotheses about the caudate, we performed a confirmatory analysis of a separate dataset in which the same subjects performed a processing speed task. A relationship between Fatigue and brain activation was evident in the caudate for this task as well. These results underscore the importance of the caudate nucleus in relation to cognitive fatigue.G. R. WylieE. DobryakovaJ. DeLucaN. ChiaravallotiK. EssadH. GenovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q G. R. Wylie E. Dobryakova J. DeLuca N. Chiaravalloti K. Essad H. Genova Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation
description	Abstract We investigated differences in brain activation associated with cognitive fatigue between persons with traumatic brain injury (TBI) and healthy controls (HCs). Twenty-two participants with moderate-severe TBI and 20 HCs performed four blocks of a difficult working memory task and four blocks of a control task during fMRI imaging. Cognitive fatigue, assessed before and after each block, was used as a covariate to assess fatigue-related brain activation. The TBI group reported more fatigue than the HCs, though their performance was comparable. Regarding brain activation, the TBI group showed a Task X Fatigue interaction in the caudate tail resulting from a positive correlation between fatigue and brain activation for the difficult task and a negative relationship for the control task. The HC group showed the same Task X Fatigue interaction in the caudate head. Because we had prior hypotheses about the caudate, we performed a confirmatory analysis of a separate dataset in which the same subjects performed a processing speed task. A relationship between Fatigue and brain activation was evident in the caudate for this task as well. These results underscore the importance of the caudate nucleus in relation to cognitive fatigue.
format	article
author	G. R. Wylie E. Dobryakova J. DeLuca N. Chiaravalloti K. Essad H. Genova
author_facet	G. R. Wylie E. Dobryakova J. DeLuca N. Chiaravalloti K. Essad H. Genova
author_sort	G. R. Wylie
title	Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation
title_short	Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation
title_full	Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation
title_fullStr	Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation
title_full_unstemmed	Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation
title_sort	cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a3bd422f18b6474f85eedf7a8f458cb5
work_keys_str_mv	AT grwylie cognitivefatigueinindividualswithtraumaticbraininjuryisassociatedwithcaudateactivation AT edobryakova cognitivefatigueinindividualswithtraumaticbraininjuryisassociatedwithcaudateactivation AT jdeluca cognitivefatigueinindividualswithtraumaticbraininjuryisassociatedwithcaudateactivation AT nchiaravalloti cognitivefatigueinindividualswithtraumaticbraininjuryisassociatedwithcaudateactivation AT kessad cognitivefatigueinindividualswithtraumaticbraininjuryisassociatedwithcaudateactivation AT hgenova cognitivefatigueinindividualswithtraumaticbraininjuryisassociatedwithcaudateactivation
_version_	1718384796493676544

Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation

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