Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2

Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2

ABSTRACT The hepatitis C virus (HCV) glycoprotein E2 is the major target of neutralizing antibodies and is therefore highly relevant for vaccine design. Its structure features a central immunoglobulin (Ig)-like β-sandwich that contributes to the binding site for the cellular receptor CD81. We show t...

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Autores principales: Ieva Vasiliauskaite, Ania Owsianka, Patrick England, Abdul Ghafoor Khan, Sarah Cole, Dorothea Bankwitz, Steven K. H. Foung, Thomas Pietschmann, Joseph Marcotrigiano, Felix A. Rey, Arvind H. Patel, Thomas Krey
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
CD81 binding site
hepatitis C virus
Ig-like domain
conformational flexibility
glycoprotein E2
monoclonal antibodies
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/a3bea6c8045c419198f363ad02f506f7
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https://doaj.org/article/a3bea6c8045c419198f363ad02f506f7

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