Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation

Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation

Abstract Background RAD51-dependent homologous recombination (HR) is one of the most important pathways for repairing DNA double-strand breaks (DSBs), and its regulation is crucial to maintain genome integrity. Elp1 gene encodes IKAP/ELP1, a core subunit of the Elongator complex, which has been impl...

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Autores principales: Wei-Ting Chen, Huan-Yi Tseng, Chung-Lin Jiang, Chih-Ying Lee, Peter Chi, Liuh-Yow Chen, Kai-Yin Lo, I-Ching Wang, Fu-Jung Lin
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Elp1
RAD51
Homologous recombination
DNA damage
Translational regulation
Medicine
R
Acceso en línea:https://doaj.org/article/a3c039a92bb749de84509f151dd98baf
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