Bisphenol S negatively affects the meotic maturation of pig oocytes

Abstract Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However,...

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Autores principales:	Tereza Žalmanová, Kristýna Hošková, Jan Nevoral, Kateřina Adámková, Tomáš Kott, Miloslav Šulc, Zora Kotíková, Šárka Prokešová, František Jílek, Milena Králíčková, Jaroslav Petr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3c199e4c7a94e34b5435a12c0cad3ce
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spelling	oai:doaj.org-article:a3c199e4c7a94e34b5435a12c0cad3ce2021-12-02T16:08:12ZBisphenol S negatively affects the meotic maturation of pig oocytes10.1038/s41598-017-00570-52045-2322https://doaj.org/article/a3c199e4c7a94e34b5435a12c0cad3ce2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00570-5https://doaj.org/toc/2045-2322Abstract Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle; (2) the failure of tubulin fibre formation, which controls proper chromosome movement; (3) changes in the supply of maternal mRNA; (4) changes in the protein amounts and distribution of oestrogen receptors α and β and of aromatase; and (5) disrupted cumulus cell expansion. Thus, these results confirm that BPS is an example of regrettable substitution because this substance exerts similar or even worse negative effects than those of the material it replaced.Tereza ŽalmanováKristýna HoškováJan NevoralKateřina AdámkováTomáš KottMiloslav ŠulcZora KotíkováŠárka ProkešováFrantišek JílekMilena KrálíčkováJaroslav PetrNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tereza Žalmanová Kristýna Hošková Jan Nevoral Kateřina Adámková Tomáš Kott Miloslav Šulc Zora Kotíková Šárka Prokešová František Jílek Milena Králíčková Jaroslav Petr Bisphenol S negatively affects the meotic maturation of pig oocytes
description	Abstract Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle; (2) the failure of tubulin fibre formation, which controls proper chromosome movement; (3) changes in the supply of maternal mRNA; (4) changes in the protein amounts and distribution of oestrogen receptors α and β and of aromatase; and (5) disrupted cumulus cell expansion. Thus, these results confirm that BPS is an example of regrettable substitution because this substance exerts similar or even worse negative effects than those of the material it replaced.
format	article
author	Tereza Žalmanová Kristýna Hošková Jan Nevoral Kateřina Adámková Tomáš Kott Miloslav Šulc Zora Kotíková Šárka Prokešová František Jílek Milena Králíčková Jaroslav Petr
author_facet	Tereza Žalmanová Kristýna Hošková Jan Nevoral Kateřina Adámková Tomáš Kott Miloslav Šulc Zora Kotíková Šárka Prokešová František Jílek Milena Králíčková Jaroslav Petr
author_sort	Tereza Žalmanová
title	Bisphenol S negatively affects the meotic maturation of pig oocytes
title_short	Bisphenol S negatively affects the meotic maturation of pig oocytes
title_full	Bisphenol S negatively affects the meotic maturation of pig oocytes
title_fullStr	Bisphenol S negatively affects the meotic maturation of pig oocytes
title_full_unstemmed	Bisphenol S negatively affects the meotic maturation of pig oocytes
title_sort	bisphenol s negatively affects the meotic maturation of pig oocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a3c199e4c7a94e34b5435a12c0cad3ce
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Bisphenol S negatively affects the meotic maturation of pig oocytes

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