Brain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.

Information that is processed with reference to oneself, i.e. Self-Referential Processing (SRP), is generally associated with better remembering compared to information processed in a condition not related to oneself. This positive effect of the self on subsequent memory performance is called as Sel...

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Autores principales:	Nastassja Morel, Nicolas Villain, Géraldine Rauchs, Malo Gaubert, Pascale Piolino, Brigitte Landeau, Florence Mézenge, Béatrice Desgranges, Francis Eustache, Gaël Chételat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3c354b317fe435c8cf050c325f0a7d3
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spelling	oai:doaj.org-article:a3c354b317fe435c8cf050c325f0a7d32021-11-18T08:29:14ZBrain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.1932-620310.1371/journal.pone.0090488https://doaj.org/article/a3c354b317fe435c8cf050c325f0a7d32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24608131/?tool=EBIhttps://doaj.org/toc/1932-6203Information that is processed with reference to oneself, i.e. Self-Referential Processing (SRP), is generally associated with better remembering compared to information processed in a condition not related to oneself. This positive effect of the self on subsequent memory performance is called as Self-Reference Effect (SRE). The neural basis of SRE is still poorly understood. The main goal of the present work was thus to highlight brain changes associated with SRE in terms of activity and functional coupling and during both encoding and retrieval so as to assess the relative contribution of both processes to SRE. For this purpose, we used an fMRI event-related self-referential paradigm in 30 healthy young subjects and measured brain activity during both encoding and retrieval of self-relevant information compared to a semantic control condition. We found that SRE was associated with brain changes during the encoding phase only, including both greater activity in the medial prefrontal cortex and hippocampus, and greater functional coupling between these brain regions and the posterior cingulate cortex. These findings highlight the contribution of brain regions involved in both SRP and episodic memory and the relevance of the communication between these regions during the encoding process as the neural substrates of SRE. This is consistent with the idea that SRE reflects a positive effect of the reactivation of self-related memories on the encoding of new information in episodic memory.Nastassja MorelNicolas VillainGéraldine RauchsMalo GaubertPascale PiolinoBrigitte LandeauFlorence MézengeBéatrice DesgrangesFrancis EustacheGaël ChételatPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90488 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nastassja Morel Nicolas Villain Géraldine Rauchs Malo Gaubert Pascale Piolino Brigitte Landeau Florence Mézenge Béatrice Desgranges Francis Eustache Gaël Chételat Brain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.
description	Information that is processed with reference to oneself, i.e. Self-Referential Processing (SRP), is generally associated with better remembering compared to information processed in a condition not related to oneself. This positive effect of the self on subsequent memory performance is called as Self-Reference Effect (SRE). The neural basis of SRE is still poorly understood. The main goal of the present work was thus to highlight brain changes associated with SRE in terms of activity and functional coupling and during both encoding and retrieval so as to assess the relative contribution of both processes to SRE. For this purpose, we used an fMRI event-related self-referential paradigm in 30 healthy young subjects and measured brain activity during both encoding and retrieval of self-relevant information compared to a semantic control condition. We found that SRE was associated with brain changes during the encoding phase only, including both greater activity in the medial prefrontal cortex and hippocampus, and greater functional coupling between these brain regions and the posterior cingulate cortex. These findings highlight the contribution of brain regions involved in both SRP and episodic memory and the relevance of the communication between these regions during the encoding process as the neural substrates of SRE. This is consistent with the idea that SRE reflects a positive effect of the reactivation of self-related memories on the encoding of new information in episodic memory.
format	article
author	Nastassja Morel Nicolas Villain Géraldine Rauchs Malo Gaubert Pascale Piolino Brigitte Landeau Florence Mézenge Béatrice Desgranges Francis Eustache Gaël Chételat
author_facet	Nastassja Morel Nicolas Villain Géraldine Rauchs Malo Gaubert Pascale Piolino Brigitte Landeau Florence Mézenge Béatrice Desgranges Francis Eustache Gaël Chételat
author_sort	Nastassja Morel
title	Brain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.
title_short	Brain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.
title_full	Brain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.
title_fullStr	Brain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.
title_full_unstemmed	Brain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.
title_sort	brain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/a3c354b317fe435c8cf050c325f0a7d3
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Brain activity and functional coupling changes associated with self-reference effect during both encoding and retrieval.

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