Epigenome editing strategies for the functional annotation of CTCF insulators

The role of CTCF-bound insulator elements in enhancer-gene interactions and transcriptional regulation remains poorly understood. Here, the authors investigate multiple epigenome editing strategies for perturbing individual CTCF-bound insulators, and evaluate their effects on genome topology and tra...

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Autores principales:	Daniel R. Tarjan, William A. Flavahan, Bradley E. Bernstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3ca68a0d6b24effa3df235e4cfa5645
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spelling	oai:doaj.org-article:a3ca68a0d6b24effa3df235e4cfa56452021-12-02T14:38:40ZEpigenome editing strategies for the functional annotation of CTCF insulators10.1038/s41467-019-12166-w2041-1723https://doaj.org/article/a3ca68a0d6b24effa3df235e4cfa56452019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12166-whttps://doaj.org/toc/2041-1723The role of CTCF-bound insulator elements in enhancer-gene interactions and transcriptional regulation remains poorly understood. Here, the authors investigate multiple epigenome editing strategies for perturbing individual CTCF-bound insulators, and evaluate their effects on genome topology and transcription.Daniel R. TarjanWilliam A. FlavahanBradley E. BernsteinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel R. Tarjan William A. Flavahan Bradley E. Bernstein Epigenome editing strategies for the functional annotation of CTCF insulators
description	The role of CTCF-bound insulator elements in enhancer-gene interactions and transcriptional regulation remains poorly understood. Here, the authors investigate multiple epigenome editing strategies for perturbing individual CTCF-bound insulators, and evaluate their effects on genome topology and transcription.
format	article
author	Daniel R. Tarjan William A. Flavahan Bradley E. Bernstein
author_facet	Daniel R. Tarjan William A. Flavahan Bradley E. Bernstein
author_sort	Daniel R. Tarjan
title	Epigenome editing strategies for the functional annotation of CTCF insulators
title_short	Epigenome editing strategies for the functional annotation of CTCF insulators
title_full	Epigenome editing strategies for the functional annotation of CTCF insulators
title_fullStr	Epigenome editing strategies for the functional annotation of CTCF insulators
title_full_unstemmed	Epigenome editing strategies for the functional annotation of CTCF insulators
title_sort	epigenome editing strategies for the functional annotation of ctcf insulators
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a3ca68a0d6b24effa3df235e4cfa5645
work_keys_str_mv	AT danielrtarjan epigenomeeditingstrategiesforthefunctionalannotationofctcfinsulators AT williamaflavahan epigenomeeditingstrategiesforthefunctionalannotationofctcfinsulators AT bradleyebernstein epigenomeeditingstrategiesforthefunctionalannotationofctcfinsulators
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Epigenome editing strategies for the functional annotation of CTCF insulators

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