Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy

Background: Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic obstructive cardiomyopathy (HOCM). Data regarding the correlations of thyroid dysfunction and the incidence of AF in HOCM are quite limited. This study aimed to reveal the correlations between different...

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Autores principales:	Li-Min Liu, Li-Shui Shen, Shang-Yu Liu, Bin Tu, Guo-Liang Li, Feng Hu, Zhi-Cheng Hu, Ling-Min Wu, Xiao-Han Fan, Li-Hui Zheng, Li-Gang Ding, Yan Yao
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a3cb1ee38f8e49188cfbe2956fe63718
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spelling	oai:doaj.org-article:a3cb1ee38f8e49188cfbe2956fe637182021-12-02T16:42:46ZCorrelations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy2095-882X10.1016/j.cdtm.2020.02.002https://doaj.org/article/a3cb1ee38f8e49188cfbe2956fe637182020-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X20300153https://doaj.org/toc/2095-882XBackground: Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic obstructive cardiomyopathy (HOCM). Data regarding the correlations of thyroid dysfunction and the incidence of AF in HOCM are quite limited. This study aimed to reveal the correlations between different thyroid status and the corresponding incidence of AF in a large HOCM cohort. Methods: A total of 806 HOCM patients with complete information on thyroid function tests and comprehensive cardiac evaluations were recruited. The participants were divided into the AF group (n = 159) and non-AF group (n = 647) according to established medical history and results of Holter monitoring. The thyroid status of the study population and the corresponding incidence of AF were assessed and analyzed. Results: Hypothyroidism accounted for the greatest proportion of thyroid dysfunction in HOCM patients. The incidence of AF significantly increased in individuals with both overt (P = 0.022) and subclinical (P = 0.007) hypothyroidism. Compared with participants in the non-AF group, those with positive AF episodes presented with lower free triiodothyronine (FT3) (2.86 ± 0.52 pg/mL vs. 3.01 ± 0.42 pg/mL, P = 0.001), higher free thyroxine (FT4) (1.24 ± 0.25 ng/dL vs. 1.15 ± 0.16 ng/dL, P < 0.001), and remarkably increased levels of thyrotropin (TSH) (12.6% vs. 5.3%, P = 0.001). Multivariable analyses demonstrated that the concentrations of FT3 (odds ratio [OR] = 0.470, 95% confidence interval [CI]: 0.272–0.813, P = 0.007) and FT4 (OR = 17.992, 95% CI: 5.750–56.296, P < 0.001), as well as TSH levels above normal ranges (OR = 2.276, 95% CI: 1.113–4.652, P = 0.024) were independently associated with the occurrence of AF in the large HOCM cohort. Conclusions: This study indicated a strong link between low thyroid function and the presence of AF in HOCM. Hypothyroidism (both overt and subclinical states) seems to be valuable for assessing the incidence of AF in patients with HOCM. Keywords: Atrial fibrillation, Hypertrophic obstructive cardiomyopathy, Hypothyroidism, Thyroid hormoneLi-Min LiuLi-Shui ShenShang-Yu LiuBin TuGuo-Liang LiFeng HuZhi-Cheng HuLing-Min WuXiao-Han FanLi-Hui ZhengLi-Gang DingYan YaoKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 6, Iss 1, Pp 35-45 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Li-Min Liu Li-Shui Shen Shang-Yu Liu Bin Tu Guo-Liang Li Feng Hu Zhi-Cheng Hu Ling-Min Wu Xiao-Han Fan Li-Hui Zheng Li-Gang Ding Yan Yao Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy
description	Background: Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic obstructive cardiomyopathy (HOCM). Data regarding the correlations of thyroid dysfunction and the incidence of AF in HOCM are quite limited. This study aimed to reveal the correlations between different thyroid status and the corresponding incidence of AF in a large HOCM cohort. Methods: A total of 806 HOCM patients with complete information on thyroid function tests and comprehensive cardiac evaluations were recruited. The participants were divided into the AF group (n = 159) and non-AF group (n = 647) according to established medical history and results of Holter monitoring. The thyroid status of the study population and the corresponding incidence of AF were assessed and analyzed. Results: Hypothyroidism accounted for the greatest proportion of thyroid dysfunction in HOCM patients. The incidence of AF significantly increased in individuals with both overt (P = 0.022) and subclinical (P = 0.007) hypothyroidism. Compared with participants in the non-AF group, those with positive AF episodes presented with lower free triiodothyronine (FT3) (2.86 ± 0.52 pg/mL vs. 3.01 ± 0.42 pg/mL, P = 0.001), higher free thyroxine (FT4) (1.24 ± 0.25 ng/dL vs. 1.15 ± 0.16 ng/dL, P < 0.001), and remarkably increased levels of thyrotropin (TSH) (12.6% vs. 5.3%, P = 0.001). Multivariable analyses demonstrated that the concentrations of FT3 (odds ratio [OR] = 0.470, 95% confidence interval [CI]: 0.272–0.813, P = 0.007) and FT4 (OR = 17.992, 95% CI: 5.750–56.296, P < 0.001), as well as TSH levels above normal ranges (OR = 2.276, 95% CI: 1.113–4.652, P = 0.024) were independently associated with the occurrence of AF in the large HOCM cohort. Conclusions: This study indicated a strong link between low thyroid function and the presence of AF in HOCM. Hypothyroidism (both overt and subclinical states) seems to be valuable for assessing the incidence of AF in patients with HOCM. Keywords: Atrial fibrillation, Hypertrophic obstructive cardiomyopathy, Hypothyroidism, Thyroid hormone
format	article
author	Li-Min Liu Li-Shui Shen Shang-Yu Liu Bin Tu Guo-Liang Li Feng Hu Zhi-Cheng Hu Ling-Min Wu Xiao-Han Fan Li-Hui Zheng Li-Gang Ding Yan Yao
author_facet	Li-Min Liu Li-Shui Shen Shang-Yu Liu Bin Tu Guo-Liang Li Feng Hu Zhi-Cheng Hu Ling-Min Wu Xiao-Han Fan Li-Hui Zheng Li-Gang Ding Yan Yao
author_sort	Li-Min Liu
title	Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy
title_short	Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy
title_full	Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy
title_fullStr	Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy
title_full_unstemmed	Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy
title_sort	correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/a3cb1ee38f8e49188cfbe2956fe63718
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Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive cardiomyopathy

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