Notch2-mediated plasticity between marginal zone and follicular B cells

Notch signalling is central to marginal zone B cell development, but it is unclear what path this development takes in vivo. Here the authors use a mouse that lacks these cells to show that transgenic induction of Notch2 is sufficient for development of marginal zone B cells via transdifferentiation...

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Auteurs principaux:	Markus Lechner, Thomas Engleitner, Tea Babushku, Marc Schmidt-Supprian, Roland Rad, Lothar J. Strobl, Ursula Zimber-Strobl
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a3cb7509c5204caea9c78545ccf13866
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id	oai:doaj.org-article:a3cb7509c5204caea9c78545ccf13866
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spelling	oai:doaj.org-article:a3cb7509c5204caea9c78545ccf138662021-12-02T14:03:51ZNotch2-mediated plasticity between marginal zone and follicular B cells10.1038/s41467-021-21359-12041-1723https://doaj.org/article/a3cb7509c5204caea9c78545ccf138662021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21359-1https://doaj.org/toc/2041-1723Notch signalling is central to marginal zone B cell development, but it is unclear what path this development takes in vivo. Here the authors use a mouse that lacks these cells to show that transgenic induction of Notch2 is sufficient for development of marginal zone B cells via transdifferentiation from follicular B cells and that this mechanism can occur in wildtype mice.Markus LechnerThomas EngleitnerTea BabushkuMarc Schmidt-SupprianRoland RadLothar J. StroblUrsula Zimber-StroblNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Markus Lechner Thomas Engleitner Tea Babushku Marc Schmidt-Supprian Roland Rad Lothar J. Strobl Ursula Zimber-Strobl Notch2-mediated plasticity between marginal zone and follicular B cells
description	Notch signalling is central to marginal zone B cell development, but it is unclear what path this development takes in vivo. Here the authors use a mouse that lacks these cells to show that transgenic induction of Notch2 is sufficient for development of marginal zone B cells via transdifferentiation from follicular B cells and that this mechanism can occur in wildtype mice.
format	article
author	Markus Lechner Thomas Engleitner Tea Babushku Marc Schmidt-Supprian Roland Rad Lothar J. Strobl Ursula Zimber-Strobl
author_facet	Markus Lechner Thomas Engleitner Tea Babushku Marc Schmidt-Supprian Roland Rad Lothar J. Strobl Ursula Zimber-Strobl
author_sort	Markus Lechner
title	Notch2-mediated plasticity between marginal zone and follicular B cells
title_short	Notch2-mediated plasticity between marginal zone and follicular B cells
title_full	Notch2-mediated plasticity between marginal zone and follicular B cells
title_fullStr	Notch2-mediated plasticity between marginal zone and follicular B cells
title_full_unstemmed	Notch2-mediated plasticity between marginal zone and follicular B cells
title_sort	notch2-mediated plasticity between marginal zone and follicular b cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3cb7509c5204caea9c78545ccf13866
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Notch2-mediated plasticity between marginal zone and follicular B cells

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