Biocontainment in Gain-of-Function Infectious Disease Research

ABSTRACT The discussion of H5N1 influenza virus gain-of-function research has focused chiefly on its risk-to-benefit ratio. Another key component of risk is the level of containment employed. Work is more expensive and less efficient when pursued at biosafety level 4 (BSL-4) than at BSL-3 or at BSL-...

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Autor principal:	W. Ian Lipkin
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a3cbd4047c0c4ae79095b9de0813f23f
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spelling	oai:doaj.org-article:a3cbd4047c0c4ae79095b9de0813f23f2021-11-15T15:39:13ZBiocontainment in Gain-of-Function Infectious Disease Research10.1128/mBio.00290-122150-7511https://doaj.org/article/a3cbd4047c0c4ae79095b9de0813f23f2012-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00290-12https://doaj.org/toc/2150-7511ABSTRACT The discussion of H5N1 influenza virus gain-of-function research has focused chiefly on its risk-to-benefit ratio. Another key component of risk is the level of containment employed. Work is more expensive and less efficient when pursued at biosafety level 4 (BSL-4) than at BSL-3 or at BSL-3 as modified for work with agricultural pathogens (BSL-3-Ag). However, here too a risk-to-benefit ratio analysis is applicable. BSL-4 procedures mandate daily inspection of facilities and equipment, monitoring of personnel for signs and symptoms of disease, and logs of dates and times that personnel, equipment, supplies, and samples enter and exit containment. These measures are not required at BSL-3 or BSL-3-Ag. Given the implications of inadvertent or deliberate release of high-threat pathogens with pandemic potential, it is imperative that the World Health Organization establish strict criteria for biocontainment that can be fairly applied in the developing world, as well as in more economically developed countries.W. Ian LipkinAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 5 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 W. Ian Lipkin Biocontainment in Gain-of-Function Infectious Disease Research
description	ABSTRACT The discussion of H5N1 influenza virus gain-of-function research has focused chiefly on its risk-to-benefit ratio. Another key component of risk is the level of containment employed. Work is more expensive and less efficient when pursued at biosafety level 4 (BSL-4) than at BSL-3 or at BSL-3 as modified for work with agricultural pathogens (BSL-3-Ag). However, here too a risk-to-benefit ratio analysis is applicable. BSL-4 procedures mandate daily inspection of facilities and equipment, monitoring of personnel for signs and symptoms of disease, and logs of dates and times that personnel, equipment, supplies, and samples enter and exit containment. These measures are not required at BSL-3 or BSL-3-Ag. Given the implications of inadvertent or deliberate release of high-threat pathogens with pandemic potential, it is imperative that the World Health Organization establish strict criteria for biocontainment that can be fairly applied in the developing world, as well as in more economically developed countries.
format	article
author	W. Ian Lipkin
author_facet	W. Ian Lipkin
author_sort	W. Ian Lipkin
title	Biocontainment in Gain-of-Function Infectious Disease Research
title_short	Biocontainment in Gain-of-Function Infectious Disease Research
title_full	Biocontainment in Gain-of-Function Infectious Disease Research
title_fullStr	Biocontainment in Gain-of-Function Infectious Disease Research
title_full_unstemmed	Biocontainment in Gain-of-Function Infectious Disease Research
title_sort	biocontainment in gain-of-function infectious disease research
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/a3cbd4047c0c4ae79095b9de0813f23f
work_keys_str_mv	AT wianlipkin biocontainmentingainoffunctioninfectiousdiseaseresearch
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Biocontainment in Gain-of-Function Infectious Disease Research

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