DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation

How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of...

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Autores principales: Wendan Ren, Huitao Fan, Sara A. Grimm, Jae Jin Kim, Linhui Li, Yiran Guo, Christopher James Petell, Xiao-Feng Tan, Zhi-Min Zhang, John P. Coan, Jiekai Yin, Dae In Kim, Linfeng Gao, Ling Cai, Nelli Khudaverdyan, Burak Çetin, Dinshaw J. Patel, Yinsheng Wang, Qiang Cui, Brian D. Strahl, Or Gozani, Kyle M. Miller, Seán E. O’Leary, Paul A. Wade, Gang Greg Wang, Jikui Song
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a3cd3e4f8bb144c1bf23822e78c3db7f
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spelling oai:doaj.org-article:a3cd3e4f8bb144c1bf23822e78c3db7f2021-12-02T15:37:56ZDNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation10.1038/s41467-021-22665-42041-1723https://doaj.org/article/a3cd3e4f8bb144c1bf23822e78c3db7f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22665-4https://doaj.org/toc/2041-1723How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of DNA methylation at repetitive LINE-1 elements.Wendan RenHuitao FanSara A. GrimmJae Jin KimLinhui LiYiran GuoChristopher James PetellXiao-Feng TanZhi-Min ZhangJohn P. CoanJiekai YinDae In KimLinfeng GaoLing CaiNelli KhudaverdyanBurak ÇetinDinshaw J. PatelYinsheng WangQiang CuiBrian D. StrahlOr GozaniKyle M. MillerSeán E. O’LearyPaul A. WadeGang Greg WangJikui SongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wendan Ren
Huitao Fan
Sara A. Grimm
Jae Jin Kim
Linhui Li
Yiran Guo
Christopher James Petell
Xiao-Feng Tan
Zhi-Min Zhang
John P. Coan
Jiekai Yin
Dae In Kim
Linfeng Gao
Ling Cai
Nelli Khudaverdyan
Burak Çetin
Dinshaw J. Patel
Yinsheng Wang
Qiang Cui
Brian D. Strahl
Or Gozani
Kyle M. Miller
Seán E. O’Leary
Paul A. Wade
Gang Greg Wang
Jikui Song
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
description How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of DNA methylation at repetitive LINE-1 elements.
format article
author Wendan Ren
Huitao Fan
Sara A. Grimm
Jae Jin Kim
Linhui Li
Yiran Guo
Christopher James Petell
Xiao-Feng Tan
Zhi-Min Zhang
John P. Coan
Jiekai Yin
Dae In Kim
Linfeng Gao
Ling Cai
Nelli Khudaverdyan
Burak Çetin
Dinshaw J. Patel
Yinsheng Wang
Qiang Cui
Brian D. Strahl
Or Gozani
Kyle M. Miller
Seán E. O’Leary
Paul A. Wade
Gang Greg Wang
Jikui Song
author_facet Wendan Ren
Huitao Fan
Sara A. Grimm
Jae Jin Kim
Linhui Li
Yiran Guo
Christopher James Petell
Xiao-Feng Tan
Zhi-Min Zhang
John P. Coan
Jiekai Yin
Dae In Kim
Linfeng Gao
Ling Cai
Nelli Khudaverdyan
Burak Çetin
Dinshaw J. Patel
Yinsheng Wang
Qiang Cui
Brian D. Strahl
Or Gozani
Kyle M. Miller
Seán E. O’Leary
Paul A. Wade
Gang Greg Wang
Jikui Song
author_sort Wendan Ren
title DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
title_short DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
title_full DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
title_fullStr DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
title_full_unstemmed DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
title_sort dnmt1 reads heterochromatic h4k20me3 to reinforce line-1 dna methylation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a3cd3e4f8bb144c1bf23822e78c3db7f
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