DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of...
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2021
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oai:doaj.org-article:a3cd3e4f8bb144c1bf23822e78c3db7f2021-12-02T15:37:56ZDNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation10.1038/s41467-021-22665-42041-1723https://doaj.org/article/a3cd3e4f8bb144c1bf23822e78c3db7f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22665-4https://doaj.org/toc/2041-1723How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of DNA methylation at repetitive LINE-1 elements.Wendan RenHuitao FanSara A. GrimmJae Jin KimLinhui LiYiran GuoChristopher James PetellXiao-Feng TanZhi-Min ZhangJohn P. CoanJiekai YinDae In KimLinfeng GaoLing CaiNelli KhudaverdyanBurak ÇetinDinshaw J. PatelYinsheng WangQiang CuiBrian D. StrahlOr GozaniKyle M. MillerSeán E. O’LearyPaul A. WadeGang Greg WangJikui SongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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Science Q Wendan Ren Huitao Fan Sara A. Grimm Jae Jin Kim Linhui Li Yiran Guo Christopher James Petell Xiao-Feng Tan Zhi-Min Zhang John P. Coan Jiekai Yin Dae In Kim Linfeng Gao Ling Cai Nelli Khudaverdyan Burak Çetin Dinshaw J. Patel Yinsheng Wang Qiang Cui Brian D. Strahl Or Gozani Kyle M. Miller Seán E. O’Leary Paul A. Wade Gang Greg Wang Jikui Song DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation |
description |
How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of DNA methylation at repetitive LINE-1 elements. |
format |
article |
author |
Wendan Ren Huitao Fan Sara A. Grimm Jae Jin Kim Linhui Li Yiran Guo Christopher James Petell Xiao-Feng Tan Zhi-Min Zhang John P. Coan Jiekai Yin Dae In Kim Linfeng Gao Ling Cai Nelli Khudaverdyan Burak Çetin Dinshaw J. Patel Yinsheng Wang Qiang Cui Brian D. Strahl Or Gozani Kyle M. Miller Seán E. O’Leary Paul A. Wade Gang Greg Wang Jikui Song |
author_facet |
Wendan Ren Huitao Fan Sara A. Grimm Jae Jin Kim Linhui Li Yiran Guo Christopher James Petell Xiao-Feng Tan Zhi-Min Zhang John P. Coan Jiekai Yin Dae In Kim Linfeng Gao Ling Cai Nelli Khudaverdyan Burak Çetin Dinshaw J. Patel Yinsheng Wang Qiang Cui Brian D. Strahl Or Gozani Kyle M. Miller Seán E. O’Leary Paul A. Wade Gang Greg Wang Jikui Song |
author_sort |
Wendan Ren |
title |
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation |
title_short |
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation |
title_full |
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation |
title_fullStr |
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation |
title_full_unstemmed |
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation |
title_sort |
dnmt1 reads heterochromatic h4k20me3 to reinforce line-1 dna methylation |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/a3cd3e4f8bb144c1bf23822e78c3db7f |
work_keys_str_mv |
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