Associations between T cells and attention problems in the general pediatric population: The Generation R study

Abstract Objective The pathogenesis of attention‐deficit/hyperactivity disorder (ADHD) is currently unclear. We hypothesized that chronic immune activation, as indexed by T and B cells, plays a role in the pathophysiology of attention problems. Therefore, we examined T and B cell subsets in a genera...

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Autores principales:	Kirsten I. M. Looman, Charlotte A. M. Cecil, Christina Grosserichter‐Wagener, Jessica C. Kiefte‐de Jong, Menno C. vanZelm, Henriëtte A. Moll
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	ADHD attention problems B cell immunology T cell Pediatrics RJ1-570 Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/a3d78de8609846d8aed0dbef3c6d621e
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spelling	oai:doaj.org-article:a3d78de8609846d8aed0dbef3c6d621e2021-11-23T06:05:44ZAssociations between T cells and attention problems in the general pediatric population: The Generation R study2692-938410.1002/jcv2.12038https://doaj.org/article/a3d78de8609846d8aed0dbef3c6d621e2021-10-01T00:00:00Zhttps://doi.org/10.1002/jcv2.12038https://doaj.org/toc/2692-9384Abstract Objective The pathogenesis of attention‐deficit/hyperactivity disorder (ADHD) is currently unclear. We hypothesized that chronic immune activation, as indexed by T and B cells, plays a role in the pathophysiology of attention problems. Therefore, we examined T and B cell subsets in a general pediatric population with information on attention problems. Methods We included 756 10‐year‐old children from the Generation R population‐based cohort. Eleven‐color flow cytometry was performed on peripheral blood samples to determine T and B cell subsets. The Child Behavior Checklist rated by parents was used to measure attention problems. Data were analyzed using linear regression analyses, adjusting for maternal and child covariates and co‐occurring childhood psychopathology. Results For T helper 1 (Th1) cells, one standard deviation (SD) increase was associated with 5.3% (95%CI 0.3; 10.5) higher attention problem scores. Furthermore, 1SD increase in CD8+ T cells was associated with 7.5% (95%CI 2.4; 12.7) higher attention problem scores. Within total CD8+ T cells, 1SD increase in naive or central memory cells was associated with 6.9% (95%CI 2.0; 12.1) and 6.4% (95%CI 1.5; 11.6) higher attention problem scores, respectively. No associations between Th2, Treg or B memory cells and attention problem scores were observed. Conclusion Higher Th1 and cytotoxic T cell numbers are associated with higher attention problem scores independent of co‐occurring psychopathology. This might indicate a possible role of a pro‐inflammatory immune profile in childhood attention problems.Kirsten I. M. LoomanCharlotte A. M. CecilChristina Grosserichter‐WagenerJessica C. Kiefte‐de JongMenno C. vanZelmHenriëtte A. MollWileyarticleADHDattention problemsB cellimmunologyT cellPediatricsRJ1-570PsychiatryRC435-571ENJCPP Advances, Vol 1, Iss 3, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ADHD attention problems B cell immunology T cell Pediatrics RJ1-570 Psychiatry RC435-571
spellingShingle	ADHD attention problems B cell immunology T cell Pediatrics RJ1-570 Psychiatry RC435-571 Kirsten I. M. Looman Charlotte A. M. Cecil Christina Grosserichter‐Wagener Jessica C. Kiefte‐de Jong Menno C. vanZelm Henriëtte A. Moll Associations between T cells and attention problems in the general pediatric population: The Generation R study
description	Abstract Objective The pathogenesis of attention‐deficit/hyperactivity disorder (ADHD) is currently unclear. We hypothesized that chronic immune activation, as indexed by T and B cells, plays a role in the pathophysiology of attention problems. Therefore, we examined T and B cell subsets in a general pediatric population with information on attention problems. Methods We included 756 10‐year‐old children from the Generation R population‐based cohort. Eleven‐color flow cytometry was performed on peripheral blood samples to determine T and B cell subsets. The Child Behavior Checklist rated by parents was used to measure attention problems. Data were analyzed using linear regression analyses, adjusting for maternal and child covariates and co‐occurring childhood psychopathology. Results For T helper 1 (Th1) cells, one standard deviation (SD) increase was associated with 5.3% (95%CI 0.3; 10.5) higher attention problem scores. Furthermore, 1SD increase in CD8+ T cells was associated with 7.5% (95%CI 2.4; 12.7) higher attention problem scores. Within total CD8+ T cells, 1SD increase in naive or central memory cells was associated with 6.9% (95%CI 2.0; 12.1) and 6.4% (95%CI 1.5; 11.6) higher attention problem scores, respectively. No associations between Th2, Treg or B memory cells and attention problem scores were observed. Conclusion Higher Th1 and cytotoxic T cell numbers are associated with higher attention problem scores independent of co‐occurring psychopathology. This might indicate a possible role of a pro‐inflammatory immune profile in childhood attention problems.
format	article
author	Kirsten I. M. Looman Charlotte A. M. Cecil Christina Grosserichter‐Wagener Jessica C. Kiefte‐de Jong Menno C. vanZelm Henriëtte A. Moll
author_facet	Kirsten I. M. Looman Charlotte A. M. Cecil Christina Grosserichter‐Wagener Jessica C. Kiefte‐de Jong Menno C. vanZelm Henriëtte A. Moll
author_sort	Kirsten I. M. Looman
title	Associations between T cells and attention problems in the general pediatric population: The Generation R study
title_short	Associations between T cells and attention problems in the general pediatric population: The Generation R study
title_full	Associations between T cells and attention problems in the general pediatric population: The Generation R study
title_fullStr	Associations between T cells and attention problems in the general pediatric population: The Generation R study
title_full_unstemmed	Associations between T cells and attention problems in the general pediatric population: The Generation R study
title_sort	associations between t cells and attention problems in the general pediatric population: the generation r study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/a3d78de8609846d8aed0dbef3c6d621e
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Associations between T cells and attention problems in the general pediatric population: The Generation R study

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