Group and individual level variations between symmetric and asymmetric DLPFC montages for tDCS over large scale brain network nodes

Abstract Two challenges to optimizing transcranial direct current stimulation (tDCS) are selecting between, often similar, electrode montages and accounting for inter-individual differences in response. These two factors are related by how tDCS montage determines current flow through the brain consi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ghazaleh Soleimani, Mehrdad Saviz, Marom Bikson, Farzad Towhidkhah, Rayus Kuplicki, Martin P. Paulus, Hamed Ekhtiari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3d7c6778cf047e1b873cda96aa858bc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a3d7c6778cf047e1b873cda96aa858bc
record_format	dspace
spelling	oai:doaj.org-article:a3d7c6778cf047e1b873cda96aa858bc2021-12-02T15:22:58ZGroup and individual level variations between symmetric and asymmetric DLPFC montages for tDCS over large scale brain network nodes10.1038/s41598-020-80279-02045-2322https://doaj.org/article/a3d7c6778cf047e1b873cda96aa858bc2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80279-0https://doaj.org/toc/2045-2322Abstract Two challenges to optimizing transcranial direct current stimulation (tDCS) are selecting between, often similar, electrode montages and accounting for inter-individual differences in response. These two factors are related by how tDCS montage determines current flow through the brain considered across or within individuals. MRI-based computational head models (CHMs) predict how brain anatomy determines electric field (EF) patterns for a given tDCS montage. Because conventional tDCS produces diffuse brain current flow, stimulation outcomes may be understood as modulation of global networks. Therefore, we developed a network-led, rather than region-led, approach. We specifically considered two common “frontal” tDCS montages that nominally target the dorsolateral prefrontal cortex; asymmetric “unilateral” (anode/cathode: F4/Fp1) and symmetric “bilateral” (F4/F3) electrode montages. CHMs of 66 participants were constructed. We showed that cathode location significantly affects EFs in the limbic network. Furthermore, using a finer parcellation of large-scale networks, we found significant differences in some of the main nodes within a network, even if there is no difference at the network level. This study generally demonstrates a methodology for considering the components of large-scale networks in CHMs instead of targeting a single region and specifically provides insight into how symmetric vs asymmetric frontal tDCS may differentially modulate networks across a population.Ghazaleh SoleimaniMehrdad SavizMarom BiksonFarzad TowhidkhahRayus KuplickiMartin P. PaulusHamed EkhtiariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ghazaleh Soleimani Mehrdad Saviz Marom Bikson Farzad Towhidkhah Rayus Kuplicki Martin P. Paulus Hamed Ekhtiari Group and individual level variations between symmetric and asymmetric DLPFC montages for tDCS over large scale brain network nodes
description	Abstract Two challenges to optimizing transcranial direct current stimulation (tDCS) are selecting between, often similar, electrode montages and accounting for inter-individual differences in response. These two factors are related by how tDCS montage determines current flow through the brain considered across or within individuals. MRI-based computational head models (CHMs) predict how brain anatomy determines electric field (EF) patterns for a given tDCS montage. Because conventional tDCS produces diffuse brain current flow, stimulation outcomes may be understood as modulation of global networks. Therefore, we developed a network-led, rather than region-led, approach. We specifically considered two common “frontal” tDCS montages that nominally target the dorsolateral prefrontal cortex; asymmetric “unilateral” (anode/cathode: F4/Fp1) and symmetric “bilateral” (F4/F3) electrode montages. CHMs of 66 participants were constructed. We showed that cathode location significantly affects EFs in the limbic network. Furthermore, using a finer parcellation of large-scale networks, we found significant differences in some of the main nodes within a network, even if there is no difference at the network level. This study generally demonstrates a methodology for considering the components of large-scale networks in CHMs instead of targeting a single region and specifically provides insight into how symmetric vs asymmetric frontal tDCS may differentially modulate networks across a population.
format	article
author	Ghazaleh Soleimani Mehrdad Saviz Marom Bikson Farzad Towhidkhah Rayus Kuplicki Martin P. Paulus Hamed Ekhtiari
author_facet	Ghazaleh Soleimani Mehrdad Saviz Marom Bikson Farzad Towhidkhah Rayus Kuplicki Martin P. Paulus Hamed Ekhtiari
author_sort	Ghazaleh Soleimani
title	Group and individual level variations between symmetric and asymmetric DLPFC montages for tDCS over large scale brain network nodes
title_short	Group and individual level variations between symmetric and asymmetric DLPFC montages for tDCS over large scale brain network nodes
title_full	Group and individual level variations between symmetric and asymmetric DLPFC montages for tDCS over large scale brain network nodes
title_fullStr	Group and individual level variations between symmetric and asymmetric DLPFC montages for tDCS over large scale brain network nodes
title_full_unstemmed	Group and individual level variations between symmetric and asymmetric DLPFC montages for tDCS over large scale brain network nodes
title_sort	group and individual level variations between symmetric and asymmetric dlpfc montages for tdcs over large scale brain network nodes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3d7c6778cf047e1b873cda96aa858bc
work_keys_str_mv	AT ghazalehsoleimani groupandindividuallevelvariationsbetweensymmetricandasymmetricdlpfcmontagesfortdcsoverlargescalebrainnetworknodes AT mehrdadsaviz groupandindividuallevelvariationsbetweensymmetricandasymmetricdlpfcmontagesfortdcsoverlargescalebrainnetworknodes AT marombikson groupandindividuallevelvariationsbetweensymmetricandasymmetricdlpfcmontagesfortdcsoverlargescalebrainnetworknodes AT farzadtowhidkhah groupandindividuallevelvariationsbetweensymmetricandasymmetricdlpfcmontagesfortdcsoverlargescalebrainnetworknodes AT rayuskuplicki groupandindividuallevelvariationsbetweensymmetricandasymmetricdlpfcmontagesfortdcsoverlargescalebrainnetworknodes AT martinppaulus groupandindividuallevelvariationsbetweensymmetricandasymmetricdlpfcmontagesfortdcsoverlargescalebrainnetworknodes AT hamedekhtiari groupandindividuallevelvariationsbetweensymmetricandasymmetricdlpfcmontagesfortdcsoverlargescalebrainnetworknodes
_version_	1718387395069476864

Group and individual level variations between symmetric and asymmetric DLPFC montages for tDCS over large scale brain network nodes

Ejemplares similares