Diagnosis of extracranial carotid stenosis by MRA of the brain

Abstract Severe extracranial carotid stenosis (SECS) patients may present with nonspecific neurological symptoms that require intracranial magnetic resonance imaging (MRI) and time-of-flight (TOF)-MR angiography (MRA) to exclude intracranial pathology. Recognition of SECS on intracranial TOF-MRA fin...

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Autores principales:	Chia-Hung Wu, Shu-Ting Chen, Jung-Hsuan Chen, Chih-Ping Chung, Chao-Bao Luo, Wei-Hsin Yuan, Feng-Chi Chang, Han-Hwa Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3d8d5105f9d4beb883ef3f6a9128371
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spelling	oai:doaj.org-article:a3d8d5105f9d4beb883ef3f6a91283712021-12-02T14:58:19ZDiagnosis of extracranial carotid stenosis by MRA of the brain10.1038/s41598-021-91511-w2045-2322https://doaj.org/article/a3d8d5105f9d4beb883ef3f6a91283712021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91511-whttps://doaj.org/toc/2045-2322Abstract Severe extracranial carotid stenosis (SECS) patients may present with nonspecific neurological symptoms that require intracranial magnetic resonance imaging (MRI) and time-of-flight (TOF)-MR angiography (MRA) to exclude intracranial pathology. Recognition of SECS on intracranial TOF-MRA findings is beneficial to provide a prompt carotid imaging study and aggressive stroke prevention. Patients with SECS (January 2016 to May 2019) undergoing percutaneous transluminal angioplasty and stenting (PTAS) were included. Differences in normalized signal intensities (SRICA) and diameters (DICA) between bilateral petrous internal carotid arteries (ICAs) were calculated 1 cm from the orifice. A hypothesized criterion describing the opacification grades (GOPH) of bilateral ophthalmic arteries was proposed. We correlated SRICA (p = 0.041), DICA (p = 0.001) and GOPH (p = 0.012), with the severity of extracranial carotid stenosis on digital subtractive angiography (DSA) in the examined group (n = 113), and all showed statistical significance in predicting percentages of ICA stenosis. The results were further validated in another patient group with SECS after radiation therapy (n = 20; p = 0.704 between the actual and predicted stenosis grades). Our findings support the evaluation of the signal ratio and diameter of intracranial ICA on TOF-MRA to achieve early diagnosis and provide appropriate management of SECS.Chia-Hung WuShu-Ting ChenJung-Hsuan ChenChih-Ping ChungChao-Bao LuoWei-Hsin YuanFeng-Chi ChangHan-Hwa HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Hung Wu Shu-Ting Chen Jung-Hsuan Chen Chih-Ping Chung Chao-Bao Luo Wei-Hsin Yuan Feng-Chi Chang Han-Hwa Hu Diagnosis of extracranial carotid stenosis by MRA of the brain
description	Abstract Severe extracranial carotid stenosis (SECS) patients may present with nonspecific neurological symptoms that require intracranial magnetic resonance imaging (MRI) and time-of-flight (TOF)-MR angiography (MRA) to exclude intracranial pathology. Recognition of SECS on intracranial TOF-MRA findings is beneficial to provide a prompt carotid imaging study and aggressive stroke prevention. Patients with SECS (January 2016 to May 2019) undergoing percutaneous transluminal angioplasty and stenting (PTAS) were included. Differences in normalized signal intensities (SRICA) and diameters (DICA) between bilateral petrous internal carotid arteries (ICAs) were calculated 1 cm from the orifice. A hypothesized criterion describing the opacification grades (GOPH) of bilateral ophthalmic arteries was proposed. We correlated SRICA (p = 0.041), DICA (p = 0.001) and GOPH (p = 0.012), with the severity of extracranial carotid stenosis on digital subtractive angiography (DSA) in the examined group (n = 113), and all showed statistical significance in predicting percentages of ICA stenosis. The results were further validated in another patient group with SECS after radiation therapy (n = 20; p = 0.704 between the actual and predicted stenosis grades). Our findings support the evaluation of the signal ratio and diameter of intracranial ICA on TOF-MRA to achieve early diagnosis and provide appropriate management of SECS.
format	article
author	Chia-Hung Wu Shu-Ting Chen Jung-Hsuan Chen Chih-Ping Chung Chao-Bao Luo Wei-Hsin Yuan Feng-Chi Chang Han-Hwa Hu
author_facet	Chia-Hung Wu Shu-Ting Chen Jung-Hsuan Chen Chih-Ping Chung Chao-Bao Luo Wei-Hsin Yuan Feng-Chi Chang Han-Hwa Hu
author_sort	Chia-Hung Wu
title	Diagnosis of extracranial carotid stenosis by MRA of the brain
title_short	Diagnosis of extracranial carotid stenosis by MRA of the brain
title_full	Diagnosis of extracranial carotid stenosis by MRA of the brain
title_fullStr	Diagnosis of extracranial carotid stenosis by MRA of the brain
title_full_unstemmed	Diagnosis of extracranial carotid stenosis by MRA of the brain
title_sort	diagnosis of extracranial carotid stenosis by mra of the brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3d8d5105f9d4beb883ef3f6a9128371
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Diagnosis of extracranial carotid stenosis by MRA of the brain

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