An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma

An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma

Oncolytic herpes simplex virus-1 lyses cancer cells while increases their immunogenicity. Blocking the CD47 “don’t eat me” signal on cancer cells promotes their phagocytosis by macrophages. Authors here show that oncolytic viruses expressing anti-CD47 antibodies improve glioblastoma survival in mous...

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Autores principales: Bo Xu, Lei Tian, Jing Chen, Jing Wang, Rui Ma, Wenjuan Dong, Aimin Li, Jianying Zhang, E. Antonio Chiocca, Balveen Kaur, Mingye Feng, Michael A. Caligiuri, Jianhua Yu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a3ded407a8e84ba2981a8d05e9d3ad5a
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spelling oai:doaj.org-article:a3ded407a8e84ba2981a8d05e9d3ad5a2021-12-02T18:37:16ZAn oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma10.1038/s41467-021-26003-62041-1723https://doaj.org/article/a3ded407a8e84ba2981a8d05e9d3ad5a2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26003-6https://doaj.org/toc/2041-1723Oncolytic herpes simplex virus-1 lyses cancer cells while increases their immunogenicity. Blocking the CD47 “don’t eat me” signal on cancer cells promotes their phagocytosis by macrophages. Authors here show that oncolytic viruses expressing anti-CD47 antibodies improve glioblastoma survival in mouse models.Bo XuLei TianJing ChenJing WangRui MaWenjuan DongAimin LiJianying ZhangE. Antonio ChioccaBalveen KaurMingye FengMichael A. CaligiuriJianhua YuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bo Xu
Lei Tian
Jing Chen
Jing Wang
Rui Ma
Wenjuan Dong
Aimin Li
Jianying Zhang
E. Antonio Chiocca
Balveen Kaur
Mingye Feng
Michael A. Caligiuri
Jianhua Yu
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
description Oncolytic herpes simplex virus-1 lyses cancer cells while increases their immunogenicity. Blocking the CD47 “don’t eat me” signal on cancer cells promotes their phagocytosis by macrophages. Authors here show that oncolytic viruses expressing anti-CD47 antibodies improve glioblastoma survival in mouse models.
format article
author Bo Xu
Lei Tian
Jing Chen
Jing Wang
Rui Ma
Wenjuan Dong
Aimin Li
Jianying Zhang
E. Antonio Chiocca
Balveen Kaur
Mingye Feng
Michael A. Caligiuri
Jianhua Yu
author_facet Bo Xu
Lei Tian
Jing Chen
Jing Wang
Rui Ma
Wenjuan Dong
Aimin Li
Jianying Zhang
E. Antonio Chiocca
Balveen Kaur
Mingye Feng
Michael A. Caligiuri
Jianhua Yu
author_sort Bo Xu
title An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
title_short An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
title_full An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
title_fullStr An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
title_full_unstemmed An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
title_sort oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a3ded407a8e84ba2981a8d05e9d3ad5a
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