The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells

Regulatory T (Treg) cells suppress immune cell activation to maintain immune homeostasis, and have their lineage enforced by the master transcription factor Foxp3. Here the authors show that Foxp3 expression is promoted and maintained by a related family member, Foxp1, specifically in peripherally i...

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Autores principales:	Sayantani Ghosh, Sinchita Roy-Chowdhuri, Keunsoo Kang, Sin-Hyeog Im, Dipayan Rudra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3e2bf22673043e1a4c02f20f2da2a40
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spelling	oai:doaj.org-article:a3e2bf22673043e1a4c02f20f2da2a402021-12-02T15:34:15ZThe transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells10.1038/s41467-018-07018-y2041-1723https://doaj.org/article/a3e2bf22673043e1a4c02f20f2da2a402018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07018-yhttps://doaj.org/toc/2041-1723Regulatory T (Treg) cells suppress immune cell activation to maintain immune homeostasis, and have their lineage enforced by the master transcription factor Foxp3. Here the authors show that Foxp3 expression is promoted and maintained by a related family member, Foxp1, specifically in peripherally induced Treg but not in Treg cells of thymic origin.Sayantani GhoshSinchita Roy-ChowdhuriKeunsoo KangSin-Hyeog ImDipayan RudraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sayantani Ghosh Sinchita Roy-Chowdhuri Keunsoo Kang Sin-Hyeog Im Dipayan Rudra The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells
description	Regulatory T (Treg) cells suppress immune cell activation to maintain immune homeostasis, and have their lineage enforced by the master transcription factor Foxp3. Here the authors show that Foxp3 expression is promoted and maintained by a related family member, Foxp1, specifically in peripherally induced Treg but not in Treg cells of thymic origin.
format	article
author	Sayantani Ghosh Sinchita Roy-Chowdhuri Keunsoo Kang Sin-Hyeog Im Dipayan Rudra
author_facet	Sayantani Ghosh Sinchita Roy-Chowdhuri Keunsoo Kang Sin-Hyeog Im Dipayan Rudra
author_sort	Sayantani Ghosh
title	The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells
title_short	The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells
title_full	The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells
title_fullStr	The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells
title_full_unstemmed	The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells
title_sort	transcription factor foxp1 preserves integrity of an active foxp3 locus in extrathymic treg cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a3e2bf22673043e1a4c02f20f2da2a40
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The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells

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