The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells

Regulatory T (Treg) cells suppress immune cell activation to maintain immune homeostasis, and have their lineage enforced by the master transcription factor Foxp3. Here the authors show that Foxp3 expression is promoted and maintained by a related family member, Foxp1, specifically in peripherally i...

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Autores principales: Sayantani Ghosh, Sinchita Roy-Chowdhuri, Keunsoo Kang, Sin-Hyeog Im, Dipayan Rudra
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a3e2bf22673043e1a4c02f20f2da2a40
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